Results 71 to 80 of about 41,806 (283)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Exact Controllability for a Class of Fractional Semilinear System of Order 1

Journal of Applied Mathematics, 2023
This paper is mainly concerned with the existence of mild solutions and exact controllability for a class of fractional semilinear system of order q∈1,2 with instantaneous and noninstantaneous impulses.
Yunhao Chu, Yansheng Liu
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Schrödinger equations in noncylindrical domains: exact controllability

International Journal of Mathematics and Mathematical Sciences, 2006
We consider an open bounded set Ω⊂ℝn and a family {K(t)}t≥0 of orthogonal matrices of ℝn. Set Ωt={x∈ℝn;x=K(t)y,for all y∈Ω}, whose boundary is Γt.
G. O. Antunes, M. D. G. da Silva, R. F. Apolaya   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Perturbations of Admissibility, Exact Controllability, Exact Observability and Regularity

, 2016
This paper is concerned with the notions of admissibility, exact controllability, exact observability and regularity of linear systems in the Banach space setting. It is proved that admissible controllability, exact controllability, admissible observation, exact observability and regularity are invariant under some regular perturbations of the ...
Mei, Zhan-Dong, Peng, Ji-Gen
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Exact Controllability of Linear Stochastic Differential Equations and Related Problems

, 2016
A notion of $L^p$-exact controllability is introduced for linear controlled (forward) stochastic differential equations, for which several sufficient conditions are established.
Wang, Yanqing, Yang, Donghui, Yong, Jiongmin, Yu, Zhiyong   +3 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Stability, stabilizability and exact controllability of a class of linear neutral type systems [PDF]

, 2009
Linear systems of neutral type are considered using the infinite dimensional approach. The main problems are asymptotic, non-exponential stability, exact controllability and regular asymptotic stabilizability.
Rabah, Rabah, Sklyar, Grigory M.
core   +3 more sources