Investigation into the effect of uncertainty of CPT-based soil type estimation on the accuracy of CPT-based pile bearing capacity analysis [PDF]
, 2016 Cone Penetration Test (CPT or CPTu) is commonly used for estimating soil types and also for the geotechnical design of pile foundation. However, the level of agreement between the CPT-based soil types and the traditional identification of soil types ...
Bellis, Angela, Hamza, Omar
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Advanced Science, EarlyView.Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu +12 more
wiley +1 more source
Приноси към българската археология, 2020 Hayredinski rampart is located in Northwestern Bulgaria. This fortification structure is part of the socalled “Western Bulgarian ramparts”, among which are also Lomski and Ostrovski ramparts. The length of the Hayredinski rampart is 24 kilometers.
Evgenia Komatarova-Balinova +1 more
doaj
Living in the industrial city: Housing quality, land ownership and the archaeological evidence from industrial Manchester, 1740-1850 [PDF]
, 2011 This paper looks at the recent archaeological evidence for industrial housing in Manchester, United Kingdom. The paper argues that a fragmented land-holding pattern developed in a number of city-centre areas during the second half of the eighteenth ...
Nevell, MD
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MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection
Advanced Science, EarlyView.MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani +6 more
wiley +1 more source
Caddo Ceramics from an Early 18th Century Spanish Mission in East Texas: Mission San Jose de los Nasonis (41RK200) [PDF]
, 2009 Mission San Jose de los Nasonis (4JRK200) and two contemporaneous Nasoni Caddo sites (41RK191 and 41RK197) were located by Mr. Bill Young more than 25 years ago in the southern part of Rusk County, Texas after the general area of the site had been ...
Marceaux, P. Shawn +2 more
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Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries
Advanced Science, EarlyView.While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang +3 more
wiley +1 more source
Renesanční podoba Pražského hradu z archeologického pohledu / The reneissance appearance of the Prague castle from an archaeological perspective [PDF]
Historie - Otázky - Problémy, 2015 This study is based on archaeological sources: a group of cesspits from houses along the north and west sides of the 3rd courtyard of the Prague Castle. A combination of historical plans, written and archaeological sources makes it possible to date all
Gabriela Blažková
doaj
A Van der Waals Material Exhibiting Room Temperature Broken Inversion Symmetry with Ferroelectricity
Advanced Science, EarlyView.This study reports a βp$\ubeta^{\text{p}}$ phase of indium selenide showing ferroelectricity over large areas at room temperature in a low‐dimensional limit. It is found that indium selenide films with βp$\ubeta^{\text{p}}$ layers display electric field‐induced switchable polarization characteristic of ferroelectric materials, suggesting the breaking ...
Fabia F. Athena +10 more
wiley +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source