Results 81 to 90 of about 219,636 (306)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Current Status of the Norman Site, 34WG2 [PDF]

, 2000
As defined by Finkelstein in his description of excavations at the site, the Norman site currently is completely located within the waters of Fort Gibson Reservoir, a U.S.
Vogele, Louis E., Jr.
core   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Finlaggan report 1: introduction and background [PDF]

, 2010
Finlaggan, Islay, the centre of the Lordship of the Isles. Excavations and fieldwork 1989-1998.
Caldwell, David H
core  

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

An Iron Age II tomb with Phoenician items at Khirbet Bir el-Kharayib, Central Palestine [PDF]

, 2020
In 2017, during a salvage excavation carried out by the Department of Antiquities and Cultural Heritage of Palestine, an Iron Age shaft tomb close to the site of Khirbet Bir el-Kharayib in Central Palestine came to light.
CAPPELLA, FEDERICO, Shawamra, Awni
core  

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

THE HISTORICAL AND ARCHEOLOGICAL EXPLORATION OF THE NORTH-WESTERN CAUCASUS IN THE FIRST HALF OF THE XIX CENTURY (ACCORDING TO THE MATERIALS OF KRASNODAR STATE ARCHIVES)

Гуманитарные и юридические исследования, 2021
The article studies the features of archeological antiquities exploration carried out in the North-Western Caucasus in the first half of the XIX century.
Y. . Klychnikov
doaj  

Fault slip in a mining context [PDF]

, 2004
Recent articles on the broad range of computational and analytic techniques currently used to investigate excavation collapse are reported. Advances in physical models are also described.
Fowkes, N.D., Mason, D.P., Napier, J.A.L.   +2 more
core  

The earliest iron-producing communities in the Lower Congo region of Central Africa : new insights from the Bu, Kindu and Mantsetsi sites [PDF]

, 2019
In 2015 the KongoKing research project team excavated the Bu, Kindu and Mantsetsi sites situated in the Kongo-Central Province of the Democratic Republic of Congo (DRC). All are part of the Kay Ladio Group.
Beeckman, Hans, Bostoen, Koen, Clist, Bernard-Olivier, Hubau, Wannes, Tshibamba Mukendi, John   +4 more
core   +1 more source