Results 61 to 70 of about 108,952 (299)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

Archaeological Sites of the Middle Kiya River: History of Discoveries and Study Prospects

open access: yesВестник Кемеровского государственного университета, 2020
The article introduces some information about the expeditionary studies on the archaeological sites located on the banks of the Middle Kiya River valley.
A. S. Savelieva   +3 more
doaj   +1 more source

The Danebury Excavations Digital Archive

open access: yes, 2003
Danebury is an Iron Age Hill Fort situated in the county of Hampshire in southern England. It has been the subject of a major programme of excavation between 1969 and 1988.
The Danebury Trust
core   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

open access: yesAdvanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao   +5 more
wiley   +1 more source

The eastern cemetery of Roman London: excavations 1983-1990

open access: yes, 2009
Archaeological excavations conducted between 1983 and 1990 at different sites within an area covering about 12ha in the modern London Borough of Tower Hamlets, to the east of the City of London, produced evidence for a large Roman cemetery. This cemetery
David Bowsher, Bruno Barber
core   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li   +21 more
wiley   +1 more source

The beginning of the study of Budjak burial mounds: historiography and cartography

open access: yesTyragetia, 2018
The article is dedicated to the history of the description and study of the Budjak burial mounds, which originates from the Tomb of the Cimmerian kings on the Dniester mentioned by Herodotus.
Igor Sapozhnikov
doaj  

SAV1 in Cooperation With FKBP52 Participates in Implantation

open access: yesAdvanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao   +10 more
wiley   +1 more source

Underground – Archaeological Research in the West Bank, 1948–1967: Management, Complexity, and Israeli Involvement

open access: yesBulletin of the History of Archaeology, 2020
The outcome of the 1948 war in Palestine resulted not only in the country’s partition between the state of Israel and the Kingdom of Jordan but also in the division of its archaeological research.
Mordechay Lash   +2 more
doaj   +1 more source

Towards Learning Boulder Excavation with Hydraulic Excavators

open access: yesCoRR
Construction sites frequently require removing large rocks before excavation or grading can proceed. Human operators typically extract these boulders using only standard digging buckets, avoiding time-consuming tool changes to specialized grippers. This task demands manipulating irregular objects with unknown geometries in harsh outdoor environments ...
Jonas Gruetter   +3 more
openaire   +2 more sources

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