Results 61 to 70 of about 1,272,486 (269)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Pelayo Pérez García, worldly philosopher: a navigation through excess

open access: yesEikasía
This review explores the life and work of Pelayo Pérez García, director of Eikasía, a Journal of Philosophy, examining his various journeys: from poetry to philosophy, from philosophical materialism to phenomenology, and from Ortiz de Urbina's work to ...
Alberto Hidalgo Tuñón
doaj   +1 more source

CRIMINAL LAW CONCEPTUALIZATION OF THE CATEGORY “OFFICIAL AUTHORITY” AS A NECESSARY PREREQUISITE FOR A UNIFORM DELINEATION OF THE CRIMES PROVIDED FOR BY ARTICLES 285 AND 286 OF THE CRIMINAL CODE OF THE RUSSIAN FEDERATION

open access: yesПравовое государство: теория и практика
The relevance of the problems of this article is due to the need to improve law enforcement practice in the field of qualification of crimes under Articles 285 and 286 of the Criminal Code of the Russian Federation.
POPOVA Evgenia Mikhailovna
doaj   +1 more source

Hegel’s Excess [PDF]

open access: yesStasis, 2016
In this article I present a reading of the transition from the first to the second books of Hegel’s Logic, focusing on the Encyclopedia Logic. In particular I investigate the notion of the excess (das Maslose), which is the final concept Hegel discusses in the first book of that version of the Logic.
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

The Proliferation of Representation in Antonin Artaud's Theatre of Cruelty and Sergei Parajanov's The Colour of Pomegranates

open access: yesFilm-Philosophy
This article argues that Antonin Artaud's theory of the theatre of cruelty, elaborated in The Theatre and Its Double, and the procedures of Sergei Parajanov's The Colour of Pomegranates (1969) bear a crucial affinity.
Alexander Dickow
doaj   +1 more source

Material Excess and Deadly Dwelling in E.L. Doctorow’s Homer and Langley

open access: yesAmerican, British and Canadian Studies Journal, 2018
In Homer and Langley, E.L. Doctorow’s 2009 novel of New York City, the author focuses on past Manhattan, which he sees as the epitome of his own self-destructive modern and contemporary society.
Schwab Anamaria
doaj   +1 more source

EXCESSIVE INTESTINAL PUTREFNCTION [PDF]

open access: yesThe American Journal of the Medical Sciences, 1895
n ...
openaire   +3 more sources

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