Results 71 to 80 of about 183,413 (314)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Determining the end of primary consolidation parameters based on settlement and excess pore water pressure [PDF]

Archives of Civil Engineering
The multiple-stage loading with reloading at EOP tests were carried out on two high-plasticity remoulded clays. One percentage of the initial value of an excess pore water pressure has been adopted as a reference for the end of the primary consolidation ...
Bartłomiej Szczepan Olek
doaj   +1 more source

Zeolitic Imidazolate Frameworks as H_2 Adsorbents: Ab Initio Based Grand Canonical Monte Carlo Simulation [PDF]

, 2010
We report the H_2 uptake behavior of 10 zeolitic−imidazolate frameworks (ZIFs), based on grand canonical Monte Carlo (GCMC) simulations. The force fields (FFs) describing the interactions between H_2 and ZIF in the GCMC were based on ab initio quantum ...
Choi, Seung-Hoon, Goddard, William A., III, Han, Sang Soo   +2 more
core   +1 more source

Does confining the hard-sphere fluid between hard walls change its average properties?

, 2007
We use grand canonical transition-matrix Monte Carlo and discontinuous molecular dynamics simulations to generate precise thermodynamic and kinetic data for the equilibrium hard-sphere fluid confined between smooth hard walls. These simulations show that
Errington, Jeffrey R., Mittal, Jeetain, Truskett, Thomas M.   +2 more
core   +1 more source

Fault reactivation by fluid injection: Controls from stress state and injection rate [PDF]

, 2018
We studied the influence of stress state and fluid injection rate on the reactivation of faults. We conducted experiments on a saw-cut Westerly granite sample under triaxial stress conditions.
Brantut, Nicolas, Mitchell, Thomas M., Passelègue, François. X.   +2 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Study of factors affecting shale gas adsorption by simplified local density-Peng–Robinson method

Energy Exploration & Exploitation, 2017
Shale gas has become an important source of natural gas, and a significant portion of gas in the reservoir exists in an adsorbed state. Thus, knowledge of gas adsorption behavior is important to estimate original gas in place and shale gas production. In
Wei Guo, Luo Zuo, Rongze Yu, Xiaowei Zhang, Li Wang   +4 more
doaj   +1 more source

Landslide motion assessment including rate effects and thermal interactions: revisiting the Canelles landslide [PDF]

, 2019
The re-activation of a large (40 Mm3) landslide on the valley slopes of a reservoir motivated a research initiative to estimate the risk of a fast-sliding mass moving into the reservoir.
Alonso Pérez de Agreda, Eduardo, Alvarado Bueno, Mauricio, Pinyol Puigmartí, Núria Mercè   +2 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Undrained Pore Pressure Development on Cohesive Soil in Triaxial Cyclic Loading

Applied Sciences, 2019
Cohesive soils subjected to cyclic loading in undrained conditions respond with pore pressure generation and plastic strain accumulation. The article focus on the pore pressure development of soils tested in isotropic and anisotropic consolidation ...
Andrzej Głuchowski, Emil Soból, Alojzy Szymański, Wojciech Sas   +3 more
doaj   +1 more source