Results 51 to 60 of about 34,549 (260)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Determining the end of primary consolidation parameters based on settlement and excess pore water pressure [PDF]

Archives of Civil Engineering
The multiple-stage loading with reloading at EOP tests were carried out on two high-plasticity remoulded clays. One percentage of the initial value of an excess pore water pressure has been adopted as a reference for the end of the primary consolidation ...
Bartłomiej Szczepan Olek
doaj   +1 more source

Prediction of Excess Pore Water Pressure during Undrained Heating of Clays

, 2015
This paper focuses on the prediction of thermally-induced excess pore water pressure generation in saturated clays during undrained heating. This study involves an analysis of experimental data presented in the literature for normally consolidated clays with different mineralogical compositions.
Ghaaowd, Ismaail, Mccartney, John S
openaire   +3 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Study of the Pore Water Pressure Development Characteristics of PHC Pipe Piles in Soft Soil Foundations

Buildings
When constructing hollow prestressed high-strength concrete (PHC) pipe piles in soft soil foundations, the generation and dissipation of pore water pressure can induce negative friction on the pile.
Zhaolin Jia, Han Wu, Shuaiqi He, Qixiang Zhao, Xiaoxu Zhang   +4 more
doaj   +1 more source

Understanding the microscopic moisture migration in pore space using DEM simulation

Journal of Rock Mechanics and Geotechnical Engineering, 2015
The deformation of soil skeleton and migration of pore fluid are the major factors relevant to the triggering of and damages by liquefaction. The influence of pore fluid migration during earthquake has been demonstrated from recent model experiments and ...
Yuan Guo, Xiong (Bill) Yu
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

In-situ tests on pore-water pressure response and consolidation mechanism of surface sediments in tidal flat of Yellow River Delta under tide and wave loading

Yantu gongcheng xuebao
In order to study the pore pressure response and consolidation mechanism of the surface sediments in the tidal flat of the Yellow River Delta under the action of wave and tide loading, the fluid sediments imitating the rapidly deposited seabed silty ...
ZHANG Jianmin 1, 2, SHAN Hongxian 3, WANG Zhenqiang 1, 2, WANG Zhicai 1, 2, WANG Jinjin 1, 2
doaj   +1 more source