Results 51 to 60 of about 36,521 (298)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Evidence for excess pore‐water pressure generated in subglacial sediment: Implications for clast ploughing

Geophysical Research Letters, 2005
Pore water pressure in front of an object pulled through subglacial sediment and water pressure at the base of a borehole were simultaneously recorded at Unteraargletscher, Switzerland, to investigate the generation of excess pore pressures downglacier from ploughing clasts.
Rousselot, Marie, Fischer, Urs H.
openaire   +1 more source

Laboratory Tests on Open-Close Pile Jacking and Load Bearing Characteristics in Saturated Clay Soil

Advances in Civil Engineering, 2022
The stress characteristics of the pile-soil interface have an important influence on the effect and long-term bearing capacity of jacked piles. In order to obtain the stress characteristics of the pile-soil interface of the jacked pile in clay, the ...
Qiang Song, Teng Zhang, Guangyu Zhou, Hongzhong Li, Xianghou Li, Yishun Jiang, Peng Zhao, Weihui Tian, Yonghong Wang, Chuantong Zhang, Huining Liu   +10 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Large-scale shaking table tests on the liquefaction and deformation responses of an ultra-deep overburden

Open Geosciences
To study the liquefaction problem of the dam foundation of an ultra-deep overburden in the strong earthquake area, a large-scale shaking table model test is carried out based on a 500 m rockfill dam project on an ultra-deep overburden.
Xing Yang, Wentao Li, Shibin Wu, Zhixiong Chen, Xuanming Ding   +4 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Analysis on Excess Pore Water Pressure Caused by Prestressed Concrete Pipes Construction in Saturated Clay Ground

, 2010
Prestressed concrete pipes construction by hammer cause high excess pore water pressure in deep soft soils because Soil disturbance by violent and poor permeability of soft soil.
Li Min Wei, Gui Hai Fu, Hui Zhou
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Prediction of Excess Pore Water Pressure during Undrained Heating of Clays

, 2015
This paper focuses on the prediction of thermally-induced excess pore water pressure generation in saturated clays during undrained heating. This study involves an analysis of experimental data presented in the literature for normally consolidated clays with different mineralogical compositions.
Ghaaowd, Ismaail, Mccartney, John S
openaire   +3 more sources