Results 131 to 140 of about 1,215,052 (269)

Investigations on Trimming Strategy and Unsteady Aerodynamic Characteristics of Tiltrotor in Conversion Procedure

Aerospace
Numerical simulations were conducted to analyze the unsteady aerodynamic characteristics of a tiltrotor aircraft with different conversion strategies.
Guoqing Zhao, Zhuangzhuang Cui, Qijun Zhao, Xi Chen, Peng Li   +4 more
doaj   +1 more source

Accelerated Aging in Survivors of Childhood Cancer—Early Onset and Excess Risk of Chronic Conditions

JAMA Oncology
ImportanceThe lifetime risk of aging-related diseases among survivors of childhood cancer, accelerated by cancer treatment exposures, is unknown. Understanding this risk can provide a more comprehensive assessment of long-term health across the lifespan of survivors and guide adult care.ObjectiveTo estimate the lifetime risks of 8 treatment-related ...
Yeh, Jennifer M., Ward, Zachary J., Stratton, Kayla L., McMahon, Mercedes V., Taylor, Chelsea S., Armstrong, Gregory T., Chow, Eric J., Hudson, Melissa M., Morton, Lindsay M., Oeffinger, Kevin C., Diller, Lisa R., Leisenring, Wendy M.   +11 more
openaire   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Towards FPGA-assisted spark: An SVM training acceleration case study

, 2016
A system that augments the Apache Spark data processing framework with FPGA accelerators is presented as a way to model and deploy FPGA-Assisted applications in large-scale clusters. In our proposed framework, FPGAs can optionally be used in place of the
Ho-Cheung Ng, Hayden Kwok-Hay So, Ho, Sam M.H., Sam M.H. Ho, Ng, Ho Cheung, Wang, Maolin, Maolin Wang, So, Hayden Kwok Hay   +7 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

S-Curve Trajectory Planning for Industrial Robots Based on Curvature Radius

Robotics
Motion planning in robotic systems, particularly in industrial contexts, must balance execution speed, precision, and safety. Excessive accelerations, especially centripetal ones in high, curvature regions, can cause vibrations, reduce tracking accuracy,
Roberto Bussola, Giovanni Incerti, Carlo Remino, Monica Tiboni   +3 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source