Results 111 to 120 of about 1,215,052 (269)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Potential of non-flat solar sail for higher characteristic acceleration [PDF]

Solar sails offer a promising means of propelling spacecraft by harnessing Solar Radiation Pressure. Although non-flat solar sails have traditionally been considered less efficient in generating thrust, altering the sails’ design to a non-flat ...
Santos Lula Barros, Letícia, Abdullah, Amirul Fiqri, Varatharajoo, Renuganth, Chak, Yew Chung, Assis da Silveira, Marcelo, Hiraki, Koju   +5 more
core   +3 more sources

Heavy-duty Casting Robot Trajectory Planning Based on the Law of Composite Polynomial Motion

Jixie chuandong, 2022
In order to further improve the stability and accuracy of the pouring trajectory of the heavy-duty casting robot during the pouring operation, a new hybrid four-degree-of-freedom heavy-duty casting robot is taken as the research object, and a trajectory ...
Wang Chengjun, Yang Lin, Li Long, Shen Yuzhe   +3 more
doaj  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Geomagnetic acceleration and rapid hydromagnetic wave dynamics in advanced numerical simulations of the geodynamo

, 2018
International audienceGeomagnetic secular acceleration, the second temporal derivative of the Earth's magnetic field, is a unique window on the dynamics taking place in the Earth's core.
Julien Aubert, Aubert, Julien
core   +1 more source

Tuning the Hydration Acceleration Efficiency of Calcium Carbonate by Pre-Seeding with Calcium Silicate Hydrate

, 2022
Nanomaterials are promising candidates for refined performance optimization of cementitious materials. In recent years, numerous studies about the performance improvement of nanomaterials using polymers have been conducted, but the modification of cement-
Xin Shu, Dongliang Zhou, Shu, Xin, Qianping Ran, Yong Yang, Ran, Qianping, Yu, Cheng, Cheng Yu, Yan, Han, Han Yan, Zhou, Dongliang, Yang, Yong   +11 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis

Acta Dermato-Venereologica, 2018
Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species.
Masutaka Furue, Akiko Hashimoto-Hachiya, Gaku Tsuji   +2 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Liquid Funk: Acceleration, late capitalism and the signification of nature in jungle drum and bass music

, 2023
Since the 1980s, the growth and popularity of electronic dance music (EDM) has challenged the Western cultural binary between nature and technology. In particular, the facilitation of all-night dancing at nightclubs, festivals, and other social dance ...
Christodoulou, C.
core