Results 101 to 110 of about 1,215,052 (269)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Quality Control of Photosystem II: Lipid Peroxidation Accelerates Photoinhibition under Excessive Illumination

PLoS ONE, 2012
Environmental stresses lower the efficiency of photosynthesis and sometimes cause irreversible damage to plant functions. When spinach thylakoids and Photosystem II membranes were illuminated with excessive visible light (100-1,000 µmol photons m(-1) s(-1)) for 10 min at either 20°C or 30°C, the optimum quantum yield of Photosystem II decreased as the ...
Tiffanie Chan, Yurika Shimizu, Pavel Pospíšil, Nobuyoshi Nijo, Anna Fujiwara, Yoshito Taninaka, Tomomi Ishikawa, Haruka Hori, Daisuke Nanba, Aya Imai, Noriko Morita, Miho Yoshioka-Nishimura, Yohei Izumi, Yoko Yamamoto, Hideki Kobayashi, Naoki Mizusawa, Hajime Wada, Yasusi Yamamoto   +17 more
openaire   +4 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Excessive cholesterol accelerates intervertebral disc degeneration by promoting the polarization of M1 macrophages

Lipids in Health and Disease
Intervertebral disc degeneration (IVDD) is the primary cause of low back pain (LBP). Dyslipidaemia can induce a chronic inflammatory state in the body, promote the polarization of macrophages, and may affect the homeostasis of the intervertebral disc (IVD).
Chang, Sheng-Jie, Xu, Hao-Wei, Zhang, Shu-Bao, Liu, Xiao-Wei, Yi, Yu-Yang, Wang, Shan-Jin   +5 more
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

An Embedded System-Based Snap Constrained Trajectory Planning Method for 3D Motion Systems

IEEE Access, 2019
Computer Numerical Control (CNC) is a technology made up of several blocks. Among these, lies the Trajectory Planning block, responsible for reference profile generation that are fed to position control loops. The need for Trajectory Planning arises from
Paulo Augusto Sherring Da Rocha, Werbeston Douglas De Oliveira, Maria Emilia De Lima Tostes   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Establishing multi-combination vehicle trajectories under acceleration from rest

, 2003
Multi-combination vehicles (MCVs) that require long times to clear intersections or railway level crossings from rest can cause excessive delay to other traffic, and compromise safety if sight distances are inadequate.
Haldane, Mandy J., Bunker, Jonathan M.
core  

Turbine thermomechanical modelling during excessive axial movement and overspeed [PDF]

, 2019
This manuscript discusses the numerical (finite element) and analytical modelling of structural interactions between gas turbine components in case of excessive axial movement and overspeed. Excessive axial movement, which may occur after a shaft failure,
Eryilmaz, Ibrahim, Pachidis, Vassilios
core   +1 more source