Results 71 to 80 of about 6,354,037 (297)

Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells

Epigenetics, 2020
In eukaryotes, nucleosomes form a barrier to DNA templated reactions and must be dynamically disrupted to provide access to the genome. During nucleosome (re)assembly, histones can be replaced by new histones, erasing post-translational modifications ...
Thom M. Molenaar, Marc Pagès-Gallego, Vanessa Meyn, Fred van Leeuwen   +3 more
doaj   +1 more source

When affective well-being is empowered : the joint role of leader-member exchange and the employment relationship [PDF]

, 2016
HRM and the leader are often assumed to play a joint role in affecting employee reactions. In a multilevel, time-lagged study, we examined the joint role of the employment relationship and leader-member exchange.
Audenaert, Mieke, Buyens, Dirk, Vanderstraeten, Alex   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An Asymmetrical Trade: Trade in the Exotic and Our Understanding of Axes and Early Neolithic Exchange

Internet Archaeology, 2009
This article explores the idea that the movement of axes away from their source of procurement, such as those of Group VI, reflects in part an invisible trade in perishable goods. In particular, it hypothesises that the pattern of movement was stimulated
Tom Clare
doaj   +1 more source

Exchange Rate Regime Choice [PDF]

The choice of an adequate exchange rate regime proves to be a highly sensitive field within which the economic authorities present and confirm themselves. The advantages and disadvantages of fixed and flexible exchange rate regimes, which have been quite
Emilija Beker
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effects of biquadratic exchange on the spectrum of elementary excitations in spin ladders

, 1998
We investigate the influence of biquadratic exchange interactions on the low-lying excitations of a S=1/2-ladder using perturbation theory, numerical diagonalization of finite systems and exact results for ladders with matrix product ground states.
Brehmer, S., Mikeska, H. -J., Mueller, M., Nagaosa, N., Uchida, S.   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

‘Don’t tell the coach’: contact breast injury and breast pain in under-18 international female rugby players

BMJ Open Sport & Exercise Medicine
Objectives Contact breast injury (CBI) and exercise-induced breast pain (EIBP) are common in adult female contact sports; however, incidence in adolescent players is unknown.
Eloise Elizabeth Kirby, Melissa Elizabeth Annie Jones, Seren Lois Evans, Vicky M Gottwald, Julian Andrew Owen   +4 more
doaj   +1 more source