Results 51 to 60 of about 3,010,681 (294)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Optimal Operation of Virtual Power Plants Based on Stackelberg Game Theory
EnergiesAs the scale of units within virtual power plants (VPPs) continues to expand, establishing an effective operational game model for these internal units has become a pressing issue for enhancing management and operations.
Weishi Zhang +5 more
doaj +1 more source
Analysis on Characteristics of Singapore′s Power Market Settlement and Risk Management
南方能源建设, 2019 [Introduction] In order to learn from the development experience of the Singapore power market, analyze its settlement and risk management characteristics, and provide suggestions for the construction of power market in South China.
HUANG Xiaoting, ZHANG Tingying, XU Zhe
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Bidding Behavior Evolution in Regional Electricity Markets Considering Renewable Energy Quotas
Zhongguo dianliWith the continuous increase of the renewable energy penetration and the increment of the adjustable units capacity, it has been an important trend for them to participate the electricity market auction transaction.
Zhe XU +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New Directions For Defense, A Big Ideas Special Event: The Next Big Bang, with Joseph Hooper [video] [PDF]
, 2016 The Big Idea Exchange (BIX)Includes presentation slidesA burning aluminum cube releases much more energy than a detonating TNT cube. What if we could force aluminum to burn very rapidly? Next generation weapons may pack a bigger bang in a smaller package
Naval Postgraduate School +1 more
core +2 more sources