Results 61 to 70 of about 6,354,037 (297)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On the contribution of exchange interactions to the Vlasov equation
, 2014 Exchange effects play an important role in determining the equilibrium properties of dense matter systems, as well as for magnetic phenomena. There exists an extensive literature concerning, e.g., the effects of exchange interactions on the equation of ...
Brodin, G., Marklund, M., Zamanian, J.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Impact of War and Conflict on People Living with Diabetes: A Scoping Review
Clinical DiabetologyOBJECTIVE: There is substantial literature detailing the interaction between war and conflict on overall human health. However, there is limited understanding of the impact of war and conflict on people living with diabetes. This scoping review describes
Emma Ospelt +10 more
doaj +1 more source
Study Investigating Prevalence of Pain in Horse Riders over Thirty-Five Years Old
International Journal of Equine Science, 2023 Horse riding is considered to be one of the most dangerous sports, more so than skiing, motor racing, and rugby. A rider will fall, on average, once every two years, and during their career, one in five are seriously injured. Previous research has looked
Victoria Lewis +3 more
doaj
Mycenaean Greece and Europe. Interconnections and exchanges in the light of recent research [PDF]
Studia Hercynia, 2022 The debate over possible connections between Bronze Age Greece and the rest of the European continent, to which Jan Bouzek made major contributions throughout his career, is reviewed in the light of new con tributions and finds.
Anthony Harding
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Scientific ReportsThe transition toward deeply decarbonized energy systems requires optimization frameworks that can simultaneously capture long-term dynamics, operational reliability, and contractual stability while managing multiple forms of uncertainty.
Liye Xie +4 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source