Results 111 to 120 of about 76,164 (271)
Frontiers in PharmacologyDrug-related acute pancreatitis (AP), acute interstitial nephritis (AIN) and drug-induced liver injury (DILI) are rare but serious adverse drug reactions (ADRs) that can have life-threatening consequences.
Olga Rogozina +5 more
doaj +1 more source
A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform
Macromolecular Rapid Communications, EarlyView.Randomized PEG (rPEG), a conceptually new PEG alternative, is combined with poly(2‐phenyl‐2‐oxazine) (PPheOzi) to establish an rPEG‐b‐PPheOzi‐b‐rPEG micellar drug delivery platform. The PPheOzi block enables high drug loadings, while competitive ELISA reveals a drastic reduction in anti‐PEG antibody affinity of rPEG in comparison to PEG.
Julian Schmidt +6 more
wiley +1 more source
Polymer International, EarlyView.Microcrystalline cellulose (MCC) was extracted from watermelon rind using acid hydrolysis. MCC can be efficiently used as reinforcement in biofilms and biocomposites. Abstract The increasing accumulation of agricultural waste from watermelon (Citrullus lanatus) represents a substantial environmental concern, particularly in view of the extensive ...
Indran Suyambulingam +7 more
wiley +1 more source
MoleculesArbidol hydrochloride is an antiviral product widely used in Russia and China for the treatment of, among other diseases, influenza. In recent years, it has turned out to be highly effective against COVID-19.
Barbara Rojek +3 more
doaj +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Sotol (Dasylirion spp.) is a resilient desert plant that sustains ecosystems, cultures and livelihoods in Chihuahua Desert. Our review highlights its nutritional properties, traditional uses and potential new applications in food, pharmaceuticals, renewable energy and water remediation. By synthesizing evidence across disciplines, we show how sotol can
Dámaris Leopoldina Ojeda Barrios +7 more
wiley +1 more source
Scientia PharmaceuticaThe design, development, and release kinetics of omeprazole (OME) from solid dosage forms have been investigated. These formulations were examined for their resilience in pH = 4.5 buffer solutions and their rate of disintegration in a small-intestine ...
Georgios Agapakis +4 more
doaj +1 more source
Challenging the Clostridium botulinum toxin type A (BoNT/A) with a selection of microorganisms by culture methods and extended storage of used vials to assess the loss of sterility [PDF]
, 2015 In 2002, botulinum toxin type A (BoNT/A) was approved by the US Food and Drug Administration (FDA) for cosmetic use. However, there may be procedural differences between the ways in which a clinician handles, applies and stores the product compared to ...
Crean, Stjohn +4 more
core
Small, EarlyView.Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi +12 more
wiley +1 more source
PharmaceuticsAdding certain excipients during the extraction process can enhance the concentration of target compounds, leading to potentially increased biological properties of the plant extract.
Jurga Andreja Kazlauskaite +2 more
doaj +1 more source
Small, EarlyView.This work explores the tailored functionalization of mesoporous silica nanoparticles (MSN) to improve the oral delivery of insulin, as a case study. Insulin confinement within silica mesopores increased drug solubility, and co‐formulation with succinylated β‐lactoglobulin yielded pH‐responsive tablets that limited gastric release and proteolysis, while
Claudia Iriarte‐Mesa +14 more
wiley +1 more source