Results 131 to 140 of about 53,055 (281)
Interdisciplinary Medicine, EarlyView.Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin +10 more
wiley +1 more source
Elemental impurity limits in excipients [PDF]
, 2013 By all accounts, analytical limit testing in USP has rarely produced positive results, implying that no individual metal was present at a higher specified limit.
Apte, Shireesh, Shireesh Apte
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Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras +2 more
wiley +1 more source
Excipients used in nano-technology assisted drug delivery systems [PDF]
, 2016 The overall therapeutic benefit of an active pharmaceutical ingredient (API) is dependent on its potency and efficacy to deliver to the site of action.
Arvind Kumar Bansal
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Refractory Eczema as a Presenting Feature of Common Variable Immunodeficiency
JEADV Clinical Practice, EarlyView.ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic inborn error of immunity (IEI) in adults. It presents with recurrent infections and non‐infectious complications, including autoimmunity, lymphoproliferation and dermatitis.
Mercedes Sanchez‐Diaz +2 more
wiley +1 more source
Manufacturing techniques and excipients used during the formulation of oil-in-water type nanosized emulsions for medical applications [PDF]
Medically, the oil-in-water nanosized emulsions are used mainly as delivery carriers for lipophilic drug molecules which show therapeutic activity when administered via parenteral, ocular and transdermal routes. To extract multifunctional activities, the
Shunmugaperumal Tamilvanan +3 more
core +1 more source
Plug-and-play excipients: an opportunity waiting to be exploited [PDF]
, 2019 Not ...
Shireesh P Apte
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Mass Spectrometry Reviews, EarlyView.ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi +6 more
wiley +1 more source
The effect of thermal and chemical modifications of excipients on the compressional properties of paracetamol tablet formulations including maize, cassava and sweet potato starches as filler-binders [PDF]
, 2016 The effects of thermal and chemical modifications on the properties of directly compressed paracetamol tablets containing cassava and sweet potato starches were compared with official maize starch.
Oludele A. Itiola +2 more
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Movement Disorders, EarlyView.Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source