Results 141 to 150 of about 53,055 (281)

Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review [PDF]

, 2010
Studies of drug-excipient compatibility represent an important phase in the pre-formulation stage for the development of all dosage forms. The potential physical and chemical interactions between drugs and excipients can affect the chemical nature, the ...
Bharate, Sandip B., Bajaj, Amrita N, Bharate, Sonali S.   +2 more
core  

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

The Journal of Excipients and Food Chemicals: Not just ‘yet another e-journal’ [PDF]

The quality of a scientific e-journal depends on the pool of knowledge, expertise, commitment and passion of its founders and editorial advisory board members and on the rigor of its peer review process.
Shireesh Apte
core   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Nutritional properties, traditional uses and potential new applications for the sotol plant (Asparagaceae, Convallarioideae): A review

PLANTS, PEOPLE, PLANET, EarlyView.
Sotol (Dasylirion spp.) is a resilient desert plant that sustains ecosystems, cultures and livelihoods in Chihuahua Desert. Our review highlights its nutritional properties, traditional uses and potential new applications in food, pharmaceuticals, renewable energy and water remediation. By synthesizing evidence across disciplines, we show how sotol can
Dámaris Leopoldina Ojeda Barrios, Antonio Martínez Ruiz, Marisela Calderón Jurado, Ramón Saúl Luján Aguirre, Juan Luis Jacobo Cuellar, Oscar Sariñana‐Aldaco, María Teresa Martínez Damián, Oscar Cruz Alvarez   +7 more
wiley   +1 more source

What does the future hold for Pharmaceutical Excipients [PDF]

Many of the excipients we use today have been around for more than fifty years. In many cases, the specifications for those excipients have not changed much over the years, either.
Chris Moreton
core   +1 more source

Effect of Resonant Mixer Granulation Parameters on Prill Properties

Propellants, Explosives, Pyrotechnics, EarlyView.
ABSTRACT Resonant mixing is a promising processing approach to manage mixing of materials with high solids content and has shown strong performance for mixing powders and pastes in energetic materials. This has led to the exploration of the approach for granulation of primary particles into millimeter‐sized agglomerates, including for generating ...
Hannah Cook, S. Emad Renfroe, Jessica Keith, Eleanor E. Radlinski, Albin Darby, Blair Brettmann   +5 more
wiley   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

The first RNAi‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Pest Management Science, EarlyView.
The approval of the RNA interference‐based biopesticide Ledprona (Calantha™) in the USA marks a milestone for RNA‐based crop protection. We discuss the regulatory implications for the European Union, highlighting opportunities, challenges, and the need for adapted risk assessment frameworks for RNA‐based plant protection products.
Aline Koch, Gabi Krczal
wiley   +1 more source

Uncharacterized and uncharacterizable attributes of macromolecular excipients [PDF]

Macromolecular excipients are unique in that each (macro)molecule or polymer chain can chemically differ significantly from another. However, these differences may not be detected across different lots or different samples because the analytical methods ...
Shireesh Apte
core   +1 more source