Results 121 to 130 of about 33,580 (237)

Detecting the Physicochemical Transformations in Solid Drug Products Stored for Long Periods of Time-Insights into DSC Application. [PDF]

Molecules
Leyk E, Konarski T, Wesolowski M.
europepmc   +1 more source

A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra‐Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the pharmacokinetics, pharmacodynamics, and safety of a novel U500 insulin aspart formulation (AT278 [500 U/mL]; AT278‐U500) compared with standard concentration insulin aspart (InsAsp [100 U/mL]; InsAsp‐U100) and U500 human regular insulin (HumIns [500 IU/mL]; HumIns‐U500). Materials and Methods This single‐centre, randomised,
Eva Svehlikova, Christina Gatschelhofer, Bettina Lackner, Maria Ratzer, Gabriele Fluhr, Anja Stoisser, Gregor Kolaric, David Gerring, Sarah Howell, Jan Jezek, Fiona Lawrence, Thomas R. Pieber   +11 more
wiley   +1 more source

Stabilization strategies and advancements in lyophilization to preserve integrity and efficacy of next-generation biologicals. [PDF]

Int J Pharm X
Maharjan R, Shin CY, Lee SK, Ha ES, Park H, Kim JS, Kim KH, Kim NA, Kim MS, Jeong SH.   +9 more
europepmc   +1 more source

A Fly in the Ointment? Non‐Target Fly Pest Benefits From Reduction in Ivermectin During Targeted Selective Treatment

Entomologia Experimentalis et Applicata, EarlyView.
Targeted Selective Treatment (TST) can reduce the rate of resistance development in livestock gastrointestinal nematodes but can also reduce the effects of anthelmintics on non‐target organisms. Most studies of non‐target anthelmintic effects focus on beneficial species.
Megan J. Lewis, Raphael K. Didham, Jacob D. Berson, Theodore A. Evans   +3 more
wiley   +1 more source

Navigating the complexity of oral peptide delivery: challenges and strategies to enhance oral bioavailability. [PDF]

Front Drug Deliv
Khalid NU, Rivera-Delgado E, von Erlach T.   +2 more
europepmc   +1 more source

Graphene oxide–modified fluoridated varnish promotes mineral recovery in demineralized bovine enamel: An in vitro study

European Journal of Oral Sciences, EarlyView.
Abstract This in vitro study evaluated the efficacy of an experimental fluoridated varnish modified with graphene oxide (GO) nanoparticles in arresting initial caries lesion progression and promoting mineral recovery in demineralized bovine enamel.
Mariana Souza Rodrigues, Guilherme José Drigo, Sofia Furlanete Raymundo, Nair Cristina Brondino, Salvatore Sauro, Velo Marilia Mattar de Amoêdo Campos   +5 more
wiley   +1 more source

Emerging Perspectives in the Formulation of Lyophilized Orally Disintegrating Tablets: From Lyoc to Self-Nanoemulsifying Lyophilized Tablets (SNELTs) and Beyond into Hybrid Platforms. [PDF]

Pharmaceutics
Popa EG, Mititelu Tartau L, Panainte AD, Păduraru L, Crețeanu A.   +4 more
europepmc   +1 more source

A film of tuberose polysaccharide supports normal epidermal keratinization by suppressing cytokine release induced by external stimuli

International Journal of Cosmetic Science, EarlyView.
(a) Dry, rough skin has an immature stratum corneum prone to stimuli, triggering IL‐1α/IL‐1ra/IL‐8 release, keratinization defects, reduced ceramide NP/NS and lipids, scaling and poor hydration. (b) TPS forms a flexible reticular film, shielding the SC, lowering cytokines, normalizing differentiation, restoring lipids and improving texture and water ...
Junko Ishikawa, Yuka Yasuda
wiley   +1 more source

Structure-based calculation of excipient effects on the viscosity of concentrated antibody solutions. [PDF]

MAbs
Shelley JC, Chai Q, Wu L, Vafaei S, Shelley MY, Feyfant E, Feng J, Woldeyes MA, Babin V, Jou JD.   +9 more
europepmc   +1 more source

Plasma Pharmacokinetic Profile of Fipronil 1% Pour‐On in Cattle: Photodegradation and the Sustained Systemic Persistence of Fipronil Sulfone

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study characterized the long‐term pharmacokinetic profile of a 1% fipronil pour‐on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC–MS/MS.
Stefani Maria Ferreira, Leonila Ester Reinert Raspantini, Giselle Kindlein, Fabiano Barreto, Caroline Andrade Tomaszewski, Tamara dos Santos Castilhos, Daniel Rodrigo Hillesheim, Silvana Lima Górniak, André Tadeu Gotardo   +8 more
wiley   +1 more source