Results 151 to 160 of about 53,055 (281)

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Establishing a Robust High Performance Liquid Chromatography-Ultraviolet Detection Technique for Nitrite Quantification in Pharmaceutical Excipients and Active Pharmaceutical Ingredients. [PDF]

J Sep Sci
Blundin K, Roy S, Mularz E, Jo J.
europepmc   +1 more source

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

Small, EarlyView.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini, Phoebe Li, Hamed Shahsavan, Mahla Poudineh   +3 more
wiley   +1 more source

Quantifying molecular specificity in excipient-driven antibody solubilization. [PDF]

MAbs
Han Z, Erkamp NA, Scrutton R, Licari G, Predeina O, Evers A, Sormanni P, Knowles TPJ.   +7 more
europepmc   +1 more source

Kirigami‐Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery

Small, EarlyView.
We have engineered a kirigami‐inspired deployable microneedle robot (KiriBot) capable of remotely controlled attachment to target tissues for sustained drug release. KiriBot incorporates a flexible structure that enhances conformability, improves adherence to irregular tissues, and facilitates microneedle insertion.
Kun Zhou, Rujie Sun, Yuyang Zuo, David J. Peeler, Jonathan Yeow, Ruoxiao Xie, Junliang Lin, Yiming Ma, Yue Shao, Yuanxiong Cao, Zhengkun Chen, Molly M. Stevens   +11 more
wiley   +1 more source

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

Smart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin, Qi Wang, Ming Zhang, Cheng Zhang, Qixian Chen, Haidong Li, Yan Zhao, Yue Wang, Jingyun Wang, Liuwei Zhang, Hongyan Cui   +10 more
wiley   +1 more source

NMR detects clustering and ultra-weak excipient interactions governing monoclonal antibody viscosity in formulation-relevant conditions. [PDF]

MAbs
Boëffard-Dosierre L, Dagallier C, Eudier G, Filipe V, Badar-Majeed A, Fraumont S, Zinn-Justin S, Theillet FX.   +7 more
europepmc   +1 more source

Clinical characteristics of immediate allergic adverse reactions to intravenous amoxicillin‒clavulanic acid in conscious dogs

Veterinary Record, EarlyView.
Abstract Background Amoxicillin‒clavulanic acid (AMC) is one of the most frequently used antibiotics in small animal practice, and reports on adverse reactions are scarce. The aim of this study was to describe the clinical characteristics of immediate allergic adverse reactions to intravenous (IV) AMC in conscious dogs. Methods The medical records of a
Leonel Frutuoso, Anna Threlfall
wiley   +1 more source

Formulation development of a biphasic release tablet-in-tablet system containing ketorolac tromethamine. [PDF]

PLoS One
Zou P, Zeng Y, Liao XR, Xie XY, Li YK, Ma YH, Liu H.   +6 more
europepmc   +1 more source

Single‐dose enflicoxib versus a 7‐day course of firocoxib for postoperative pain control in dogs undergoing orthopaedic surgery: A multicentre, randomised, masked, non‐inferiority study

Veterinary Record, EarlyView.
Abstract Background Perioperative analgesia is essential in dogs undergoing orthopaedic surgery, and enflicoxib's long duration makes single‐dose administration attractive. Methods A prospective, multicentre, randomised, masked trial compared enflicoxib (8 mg/kg) given 24 hours before surgery with firocoxib (5 mg/kg) given daily for 7 days. Two hundred
Marta Salichs, José I. Redondo, Anabel Blasco‐Moreno, Llorenç Badiella, Josep Homedes   +4 more
wiley   +1 more source