Results 81 to 90 of about 77,170 (289)

In situ rewiring TAMs as annihilators by “Spark-relay” nanoinitiator with flexible reactant ratio for amplifying solid tumor immunotherapy

open access: yesActa Pharmaceutica Sinica B
Tailoring tumor-associated macrophages (TAMs) into the tumoricidal phenotype represents a high-profile strategy for tumor immunotherapy. However, the existing TAMs repolarization strategies are restricted by hostile microenvironmental stress and ...
Xinping Luo   +6 more
doaj   +1 more source

Hydrophilic Matrices for Oral Control Drug Delivery [PDF]

open access: yes, 2015
Oral controlled drug delivery has gathered tremendous attention over the years due to its many advantages over conventional dosage forms. Polymer-based matrices have become an integral part of the pharmaceutical industry. Hydrophilic matrices are capable
Conway, Barbara R, Ghori, Muhammad U.
core   +1 more source

Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]

open access: yes, 2020
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham   +3 more
core   +1 more source

A review on the role of co-processed excipients in tablet formulations

open access: yesHybrid Advances
Multifunctional excipients are becoming more popular since they eliminate the need to combine numerous excipients in a mixture, simplifying the drug formulation process. The multifunctional excipients include co-processed excipients, which add additional
Ankita S. Burande   +7 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort   +8 more
wiley   +1 more source

Development of the composition of the tablets "Cardiosten" using the method of mathematical planning of the experiment

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
The aim of the work is devoted to the substantiation of the choice of excipients while the development of Cardiosten tablets with a dry extract from a mixture of medicinal plant materials of cardiological action, taking into account the application of ...
O. S. Kukhtenko, Ye. V. Hladukh
doaj   +1 more source

Tribo-electrification and Powder Adhesion Studies in the Development of Polymeric Hydrophilic Drug Matrices [PDF]

open access: yes, 2015
The generation of tribo-electric charge during pharmaceutical powder processing can cause a range of complications, including segregation of components leading to content uniformity and particle surface adhesion.
Barbara Conway   +7 more
core   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay   +5 more
wiley   +1 more source

Karakterisasi Agar dari Hasil Produksi Petani Kabupaten Brebes sebagai Eksipien Mukoadesif dalam Sediaan Farmasi

open access: yesJournal of Tropical Pharmacy and Chemistry, 2016
Agar is widely used as a tablet binder, gel base, cream base, and the others in the manufacture of pharmaceutical dosage forms. Mucoadhesive drug delivery is expected to prolong the contact time of the drug in the mucus so that the maximum effect of the
Dhadhang Wahyu Kurniawan   +2 more
doaj   +1 more source

Pharmaco-technological researches for development of tablets composition with amlodipin and enalapril

open access: yesФармацевтичний журнал, 2020
Ukraine has one of the highest mortality rates from cardiovascular diseases in Europe, accounting for 772.1 cases among men and 440.9 among women per 100 000 population.
N. S. Behei, O. V. Tryhubchak
doaj   +1 more source

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