Results 81 to 90 of about 53,055 (281)
Functionality specific excipients influencing manufacturability and/or processing of pharmaceutical dosage forms: a wish list [PDF]
, 2013 The non-availability of suitable excipients that perform specific functions in manufacturing unit operations or during storage leads to suboptimal processes and formulations.
Apte, Shireesh, Shireesh Apte
core
Shipin gongye ke-jiIn this study, Astragalus composite granular tea was prepared by decocting, concentrating, granulation and drying processes of the twelve kinds of dietary Chinese herbs such as Astragalus, Salvia miltiorrhiza and Panax notoginseng.
Lixia WANG +6 more
doaj +1 more source
Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery
Journal of Applied Polymer Science, EarlyView.Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale +3 more
wiley +1 more source
Absorption enhancing excipients in systemic nasal drug delivery [PDF]
, 2016 Intranasal drug delivery is becoming an increasingly important form of drug administration for chronic and chronic-intermittent diseases. Important new applications currently in development include drugs for diabetes, osteoporosis, obesity, certain types
Maggio ET
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British Journal of Clinical Pharmacology, EarlyView.Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort +8 more
wiley +1 more source
Handbook of Pharmaceutical excipients [PDF]
, 2009 Pharmaceutical dosage forms contain both pharmacologically active compounds and excipients added to aid the formulation and manufacture of the subsequent dosage form for administration to patients. Indeed, the properties of the final dosage form (i.e.
Quinn, Marian +2 more
core +1 more source
Characterization of solid excipients: delving deeper by probing the surface [PDF]
, 2011 Performance differences in different lots of solid excipients often cannot be detected by bulk physicochemical methods. This is because some of these (performance) differences originate at the surface of individual excipient particles, accounting for ...
Apte, Shireesh, Shireesh Apte
core
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review [PDF]
, 2016 Studies of active drug/excipient compatibility represent an important phase in the preformulation stage of the development of all dosage forms. The potential physical and chemical interactions between drugs and excipients can affect the chemical nature ...
Sandip B. Bharate +2 more
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British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source