Results 71 to 80 of about 53,055 (281)

Uncharacterized and uncharacterizable attributes of macromolecular excipients [PDF]

, 2010
Macromolecular excipients are unique in that each (macro)molecule or polymer chain can chemically differ significantly from another. However, these differences may not be detected across different lots or different samples because the analytical methods ...
Apte, Shireesh, Shireesh Apte
core  

Nanostructured Deep Eutectic Systems in Healthcare: From Bioactive Solvents to Intelligent Biointerfaces, Wearables, and AI‐Driven Design

Advanced NanoBiomed Research, EarlyView.
Beyond the green solvent paradigm, this review redefines Deep Eutectic Systems (DES) as programmable supramolecular nanoassemblies. We survey their biomedical convergence: stabilizing thermolabile mRNA to enable cold chain‐free logistics, reshaping transdermal microneedle delivery, enabling long‐term wearables via eutectogels, and utilizing Generative ...
Jeesu Moon, Min Seo Kim, Jae‐Seung Lee
wiley   +1 more source

Methods of Thermal Analysis as Fast and Reliable Tools for Identification and Quantification of Active Ingredients in Commercially Available Drug Products

Pharmaceutics
Background/Objectives: Drug products on the pharmaceutical market must meet a number of requirements that guarantee their quality, safety, and efficacy.
Marek Wesolowski
doaj   +1 more source

Understanding the implications of pharmaceutical excipients and additives in the treatment of diabetic foot ulcers [PDF]

, 2016
A diabetic foot ulcer (DFU) is a consequence of Diabetes Mellitus (DM) and involves complex pathological processes. Among diabetic patients DFU is a major cause of deaths resulting from the amputation of the lower limbs. Various treatment strategies have
Gowthamarajan Kuppusamy, Veera Venkata Satyanarayana Reddy Karri, Shashank Mulukutla, Sumeet Sood, Rajkumar Malayandi   +4 more
core  

Complexing Protein-Free Botulinum Neurotoxin A Formulations: Implications of Excipients for Immunogenicity

Toxins
The formation of neutralizing antibodies is a growing concern in the use of botulinum neurotoxin A (BoNT/A) as it may result in secondary treatment failure.
Michael Uwe Martin, Juergen Frevert, Clifton Ming Tay   +2 more
doaj   +1 more source

The potential of excipients to improve the efficiency of immuno-oncology therapy. [PDF]

, 2017
The cocktail of substances used in cell culture media to cryopreserve, transfect, grow, expand, fractionate, concentrate, wash and remove impurities from leukapheresis harvested T-cells are functional excipients.
Shireesh Apte
core  

Characterization of functionalized calcium carbonate as a new pharmaceutical excipient [PDF]

, 2014
Excipients are indispensable functional components, which are used to develop innovative, robust, and reproducible formulations with good patient compliance due to optimized plasma concentrations and less side effects.
Stirnimann, Tanja
core   +1 more source

Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived Chaetomium sp. fungus

Natural Products and Bioprospecting
Five new heterodimers, chalasoergodimers A–E (1–5), and three known heterodimers (6–8), along with four chaetoglobosin monomers (9–12), were isolated from a marine-derived Chaetomium sp. fungus.
Ze-Hong Lin, Han-Wen Shan, Li-Kun Yang, Tian-Tian Sun, Li-Ying He, Hui-Fang Du, Ya-Hui Zhang, Shan Liu, Xu Wang, Du-Qiang Luo, Fei Cao   +10 more
doaj   +1 more source

Host–Guest Complexation of Olmesartan Medoxomil by Heptakis(2,6-di-O-methyl)-β-cyclodextrin: Compatibility Study with Excipients

Pharmaceutics
Background: Olmesartan medoxomil (OLM) is the prodrug of olmesartan, an angiotensin II type 1 receptor blocker that has antihypertensive and antioxidant activities and renal protective properties.
Dana Emilia Man, Ema-Teodora Nițu, Claudia Temereancă, Laura Sbârcea, Adriana Ledeți, Denisa Ivan, Amalia Ridichie, Minodora Andor, Alex-Robert Jîjie, Paul Barvinschi, Gerlinde Rusu, Renata-Maria Văruţ, Ionuț Ledeți   +12 more
doaj   +1 more source

Macromolecular excipients exert biological effects via their microbial fermentation absorbable products. [PDF]

, 2016
Fermentation of these macromolecular food or pharmaceutical excipient ingredients by the gut microbiota leads to the formation of short chain fatty acids (SCFA) which can be absorbed from the gut into the general circulation.
Shireesh Apte
core