Results 51 to 60 of about 33,580 (237)

Karakterisasi Agar dari Hasil Produksi Petani Kabupaten Brebes sebagai Eksipien Mukoadesif dalam Sediaan Farmasi

Journal of Tropical Pharmacy and Chemistry, 2016
Agar is widely used as a tablet binder, gel base, cream base, and the others in the manufacture of pharmaceutical dosage forms. Mucoadhesive drug delivery is expected to prolong the contact time of the drug in the mucus so that the maximum effect of the
Dhadhang Wahyu Kurniawan, Arif Budianto, Khilman Husna Pratama   +2 more
doaj   +1 more source

Pharmaco-technological researches for development of tablets composition with amlodipin and enalapril

Фармацевтичний журнал, 2020
Ukraine has one of the highest mortality rates from cardiovascular diseases in Europe, accounting for 772.1 cases among men and 440.9 among women per 100 000 population.
N. S. Behei, O. V. Tryhubchak
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations

Pharmaceutics, 2018
Protein-based therapeutics are considered to be one of the most important classes of pharmaceuticals on the market. The growing need to prolong stability of high protein concentrations in liquid form has proven to be challenging.
Akash Pandya, Mark J. Howard, Mire Zloh, Paul A. Dalby   +3 more
doaj   +1 more source

Nanostructured Deep Eutectic Systems in Healthcare: From Bioactive Solvents to Intelligent Biointerfaces, Wearables, and AI‐Driven Design

Advanced NanoBiomed Research, EarlyView.
Beyond the green solvent paradigm, this review redefines Deep Eutectic Systems (DES) as programmable supramolecular nanoassemblies. We survey their biomedical convergence: stabilizing thermolabile mRNA to enable cold chain‐free logistics, reshaping transdermal microneedle delivery, enabling long‐term wearables via eutectogels, and utilizing Generative ...
Jeesu Moon, Min Seo Kim, Jae‐Seung Lee
wiley   +1 more source

Methods of Thermal Analysis as Fast and Reliable Tools for Identification and Quantification of Active Ingredients in Commercially Available Drug Products

Pharmaceutics
Background/Objectives: Drug products on the pharmaceutical market must meet a number of requirements that guarantee their quality, safety, and efficacy.
Marek Wesolowski
doaj   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived Chaetomium sp. fungus

Natural Products and Bioprospecting
Five new heterodimers, chalasoergodimers A–E (1–5), and three known heterodimers (6–8), along with four chaetoglobosin monomers (9–12), were isolated from a marine-derived Chaetomium sp. fungus.
Ze-Hong Lin, Han-Wen Shan, Li-Kun Yang, Tian-Tian Sun, Li-Ying He, Hui-Fang Du, Ya-Hui Zhang, Shan Liu, Xu Wang, Du-Qiang Luo, Fei Cao   +10 more
doaj   +1 more source

Complexing Protein-Free Botulinum Neurotoxin A Formulations: Implications of Excipients for Immunogenicity

Toxins
The formation of neutralizing antibodies is a growing concern in the use of botulinum neurotoxin A (BoNT/A) as it may result in secondary treatment failure.
Michael Uwe Martin, Juergen Frevert, Clifton Ming Tay   +2 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source