Results 51 to 60 of about 46,206 (287)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

USP’s characterization of commercial poly(lactic-co-glycolic acid) utilizing SEC-Multi-Angle Light Scattering and Refractive Index techniques via Absolute Method approach

Journal of Pharmaceutical and Biomedical Analysis Open
This research focuses on evaluating the data quality and reliability of Size Exclusion Chromatography with Multi-Angle Light Scattering and Refractive Index (SEC-MALS/RI) chromatography in determining molecular weight-related parameters in poly(lactic-co-
Yixin Ren, Leo Liu, Yang Liu, Weidong Zhao, Peng Zhang, Hong Wang, Catherine Sheehan, Michael Ambrose   +7 more
doaj   +1 more source

Anti-diabetic effects of excipients: possibility of formulation of an anti-diabetic dosage form using pharmaceutical excipients or their constituents, or food additives [PDF]

, 2010
The ability of pharmaceutical excipients to exhibit significant bioactivity independent of the active pharmaceutical ingredient is beginning to be recognized. Certain types of diets or foods have been demonstrated to alleviate diabetic symptoms.
Apte, Shireesh, Shireesh Apte
core  

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

In situ rewiring TAMs as annihilators by “Spark-relay” nanoinitiator with flexible reactant ratio for amplifying solid tumor immunotherapy

Acta Pharmaceutica Sinica B
Tailoring tumor-associated macrophages (TAMs) into the tumoricidal phenotype represents a high-profile strategy for tumor immunotherapy. However, the existing TAMs repolarization strategies are restricted by hostile microenvironmental stress and ...
Xinping Luo, Yingmeng Jiang, Qing Zhang, Jie Yu, Chenxi Zhou, Zhanwei Zhou, Minjie Sun   +6 more
doaj   +1 more source

Pharmaceutical excipients - the continuing paradox(es) of formulation science [PDF]

, 2016
One of the paradoxes of pharmaceutical formulation science is that, although excipients do not treat the disease, the disease cannot be treated without them.
R. Christian Moreton
core  

The safety of pharmaceutical excipients [PDF]

Il Farmaco, 2003
The most important part of a medicine as far as its weight is concerned, is constituted by its excipients, which have the important functions of guaranteeing the dosage, stability and bioavailability of the active principle. The components employed as excipients must present the characteristics required by their technological function but, as with any ...
PIFFERI, GIORGIO, P. Restani
openaire   +3 more sources

Can analytical testing of excipients be ‘volkswagenized’? [PDF]

, 2016
In light of the Volkswagenscandal, where software was surreptitiouslyinstalled to generate false, in-specification,results when the automobile was tested for emissions, it is prudent to examine whether a similar stratagem can be applied to the ...
Shireesh Apte
core  

Embedding Chemistry and Pharmacy Into Sustainability

Angewandte Chemie International Edition, EarlyView.
Chemistry and pharmacy provide products and processes that are indispensable for our high living standard. To understand their relationship with sustainability is important to allow them to contribute to sustainability in a sustainable manner. An integrated overview of green, circular, and sustainable chemistry and pharmacy is given and how they have t
Klaus Kümmerer
wiley   +1 more source