Results 31 to 40 of about 46,206 (287)

Quantification of clarithromycin polymorphs in presence of tablet excipients [PDF]

, 2016
Excipients can cause a considerable challenge when developing a solid form of an active pharmaceutical ingredient (API). The aim of this present study was to analyze the polymorphs of clarithromycin (CAM) mixed with excipients using powder X-ray ...
Ganesh Shete, Arvind Kumar Bansal, Swathi Kuncham   +2 more
core  

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

The Current States, Challenges, Ongoing Efforts, and Future Perspectives of Pharmaceutical Excipients in Pediatric Patients in Each Country and Region

Children, 2022
A major hurdle in pediatric formulation development is the lack of safety and toxicity data on some of the commonly used excipients. While the maximum oral safe dose for several kinds of excipients is known in the adult population, the doses in pediatric
Jumpei Saito, Anjali Agrawal, Vandana Patravale, Anjali Pandya, Samuel Orubu, Min Zhao, Gavin P. Andrews, Caroline Petit-Turcotte, Hannah Landry, Alysha Croker, Hidefumi Nakamura, Akimasa Yamatani, Smita Salunke   +12 more
doaj   +1 more source

Interaction and compatibility studies of efavirenz with pharmaceutical excipients [PDF]

, 2016
Although excipients have traditionally been thought of as being inert, experience has shown that there can be interactions between excipients and drugs. Thus, knowledge of potential physical and chemical interactions can be very useful. The compatibility
Helvécio Vinícius Antunes Rocha, Andrea Mariela Araya-Sibaja, Rafael Nicolay Pereira, Carlos Eduardo Maduro de Campos, Cristiane Rodrigues Drago Hoffmeister, Marco Antônio Segatto Silva, Cinira Fandaruff, Silvia Lucia Cuffini   +7 more
core  

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

The Influence of Excipients’ Chemical Nature on the Degradation of Metformin and Vildagliptin [PDF]

Kemija u Industriji
The influence of the chemical nature of excipients (magnesium stearate, povidone, microcrystalline cellulose, lactose, crospovidone, and talc) on the degradation of metformin and vildagliptin was tested by forced degradation, using acid hydrolysis, base ...
Amra Demirović, Alija Uzunović, Anisa Veledar-Hamalukić   +2 more
doaj   +1 more source

Excipients used in lyophilization of small molecules [PDF]

, 2010
This review deals with the excipients used in various lyophilized formulations of small molecules. The role of excipients such as bulking agents, buffering agents, tonicity modifiers, antimicrobial agents, surfactants and co-solvents has been discussed ...
Arvind Kumar Bansal, Kumar, Lokesh, Ankit Baheti, Baheti, Ankit, Lokesh Kumar, Bansal, Arvind Kumar   +5 more
core  

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Considerations for setting specifications for excipients of natural origin [PDF]

, 2016
Setting, non-onerous and relevant specifications for excipients derived from natural sources is further complicated by the fact that precedents for setting specifications for such novel materials are few and the range of properties that are critical to ...
Shireesh Apte
core  

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source