Results 31 to 40 of about 35,554 (218)
Acta Pharmaceutica Sinica BThe αPD-L1 antibody-based immune checkpoint blockade therapy is still limited by the poor clinical response rate as it is mainly utilized to block surface PD-L1 on tumor cells while ignoring abundant PD-L1 exosomes secreted in the environment, causing ...
Zheng Wang +5 more
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The Influence of Excipients’ Chemical Nature on the Degradation of Metformin and Vildagliptin [PDF]
Kemija u IndustrijiThe influence of the chemical nature of excipients (magnesium stearate, povidone, microcrystalline cellulose, lactose, crospovidone, and talc) on the degradation of metformin and vildagliptin was tested by forced degradation, using acid hydrolysis, base ...
Amra Demirović +2 more
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Фармацевтичний журнал, 2021 The available range of phytopreparations for topical use in the oral cavity does not fully meet the needs of patients as mainly medicinal plant raw materials and tinctures of domestic production represent it.
O. I. Hordiienko, T. A. Hroshovyi
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ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway
Molecular MedicineOsteoporosis (OP) is a common systemic metabolic bone disease characterized by the decrease in bone mass and hyperactivity of osteoclasts. ACT001 is approved as an orphan drug by FDA and has shown multiple protective effects against tissue injury ...
Yuan Li +9 more
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Angewandte Chemie International Edition, EarlyView.Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber +21 more
wiley +1 more source
Molecules, 2013 Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of
Christopher Wai-Kei Lam +2 more
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Molecules, 2021 Background: DNA-RNA compounds have shown promising protection against cell oxidative stress. This study aimed to assess the cytotoxicity, protective, or preventive effect of different experimental formulations on oral epithelia’s oxidative stress in ...
Andrei C. Ionescu +5 more
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The tRNA‐Modification Geranyl‐2‐Thiouridine Enables RNA‐Lipid Association
Angewandte Chemie International Edition, EarlyView.We report the preparation of mono‐ to tri‐geranylated RNA and the association of the hydrophobic RNA with membranes for future efficient incorporation of RNA into liposomes. ABSTRACT The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of
Johannes Singer +3 more
wiley +1 more source
DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CAPSULES WITH OIL OF VIBURNUM
Фармация и фармакология (Пятигорск), 2015 The article presents results of a study of excipients selection to create a capsule. We have presented an obtainment technology for the gelatin capsules with Viburnum oil.
A. V. Brazhenko +2 more
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Molecules, 2021 Risperidone (RSP) is an atypical antipsychotic drug used in treating schizophrenia, behavioral, and psychological symptoms of dementia and irritability associated with autism.
Laura Sbârcea +9 more
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