Results 31 to 40 of about 53,055 (281)

Conformal Thermoreversible Gelatin‐Based Gel for High‐Fidelity Electrophysiological Recording and Acute Peripheral Nerve Interfacing

Advanced Materials, EarlyView.
A thermoreversible gelatin‐based gel forms a soft, conformal bioelectronic interface on complex biological surfaces. The flowable precursor penetrates hair‐dense regions, solidifies in situ, and maintains low impedance through adaptive contact and hydration retention.
Ruinan Hao, Yong Yuan, Jie Gao, Tong Wang, Jinzhi Du, Feng Tian, Xiaoli Li, Ruirui Qiao, Liqun Zhang, Jiajia Xue   +9 more
wiley   +1 more source

Inhaled nucleic acid delivery systems for the treatment of pulmonary interstitial diseases: Challenges and opportunities

Acta Pharmaceutica Sinica B
The treatment of interstitial lung diseases (ILDs) was important to reduce the inflammation or fibrosis within the interstitial space. In recent years, a variety of undruggable ILDs targets were emerged for anti-inflammation and anti-fibrosis therapy ...
Jingwen Dong, Jiahui Chen, Junmei Mu, Yinuo Fan, Jinsu Wang, Qiyan Zhang, Lin Zhang, Zhanwei Zhou, Minjie Sun   +8 more
doaj   +1 more source

Interaction and compatibility studies of efavirenz with pharmaceutical excipients [PDF]

, 2016
Although excipients have traditionally been thought of as being inert, experience has shown that there can be interactions between excipients and drugs. Thus, knowledge of potential physical and chemical interactions can be very useful. The compatibility
Helvécio Vinícius Antunes Rocha, Andrea Mariela Araya-Sibaja, Rafael Nicolay Pereira, Carlos Eduardo Maduro de Campos, Cristiane Rodrigues Drago Hoffmeister, Marco Antônio Segatto Silva, Cinira Fandaruff, Silvia Lucia Cuffini   +7 more
core  

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

The Influence of Excipients’ Chemical Nature on the Degradation of Metformin and Vildagliptin [PDF]

Kemija u Industriji
The influence of the chemical nature of excipients (magnesium stearate, povidone, microcrystalline cellulose, lactose, crospovidone, and talc) on the degradation of metformin and vildagliptin was tested by forced degradation, using acid hydrolysis, base ...
Amra Demirović, Alija Uzunović, Anisa Veledar-Hamalukić   +2 more
doaj   +1 more source

Excipients used in lyophilization of small molecules [PDF]

, 2010
This review deals with the excipients used in various lyophilized formulations of small molecules. The role of excipients such as bulking agents, buffering agents, tonicity modifiers, antimicrobial agents, surfactants and co-solvents has been discussed ...
Arvind Kumar Bansal, Kumar, Lokesh, Ankit Baheti, Baheti, Ankit, Lokesh Kumar, Bansal, Arvind Kumar   +5 more
core  

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Study of the quantitative factors influence on pharmaco-technological properties of powder masses and tablets with plant extracts and essential oil

Фармацевтичний журнал, 2021
The available range of phytopreparations for topical use in the oral cavity does not fully meet the needs of patients as mainly medicinal plant raw materials and tinctures of domestic production represent it.
O. I. Hordiienko, T. A. Hroshovyi
doaj   +1 more source

Considerations for setting specifications for excipients of natural origin [PDF]

, 2016
Setting, non-onerous and relevant specifications for excipients derived from natural sources is further complicated by the fact that precedents for setting specifications for such novel materials are few and the range of properties that are critical to ...
Shireesh Apte
core  

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source