Results 11 to 20 of about 53,055 (281)

Automation and Active Learning for the Multi-Objective Optimization of Antibody Formulations. [PDF]

Adv Sci (Weinh)
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
Radford DC, Tamasi M, Di Mare E, Gormley AJ.   +3 more
europepmc   +2 more sources

“Petal-like” size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy

Journal of Nanobiotechnology, 2021
Background Breast cancer is the fastest-growing cancer among females and the second leading cause of female death. At present, targeted antibodies combined with hyperthermia locally in tumor has been identified as a potential combination therapy to ...
Yanan Li, Wenting Song, Yumin Hu, Yun Xia, Zhen Li, Yang Lu, Yan Shen   +6 more
doaj   +1 more source

Influence of Excipients and Pressing Force on the Impurity Content of N-(4-aminobenzoyl)-L-glutamic Acid in Folic Acid Drugs During Storage

Разработка и регистрация лекарственных средств, 2023
Introduction. Excipients, impurities contained in them, and sorbed water are one of the reasons for degradation of the active pharmaceutical substance (API). Excipients effect should be especially evaluated for moisture-sensitive APIs. Folic acid (FA) is
N. A. Obraztsova, A. A. Samsonov, M. A. Kovtunenko, V. N. Shmeleva, N. A. Golubeva   +4 more
doaj   +1 more source

Study of the technological properties of excipients in the development of the composition of orally dispersible tablets

Разработка и регистрация лекарственных средств, 2021
Introduction. The article presents the results of studying the technological properties of individual excipients widely used in the compositions of existing orally dispersed tablets (ODT) for subsequent planning a multifactorial experiment.
I. D. Kasymov, A. V. Basevich
doaj   +1 more source

Surface modification of pure titanium to improve its anti-inflammatory function

European Journal of Inflammation, 2015
Objective: Surface-modified titanium material was prepared to explore its corrosion resistance and microbial adhesion. Methods: Atmospheric pressure plasma was used to modify the surface of pure titanium. The surface morphology and adhesion morphology of
Hanwen Sun, Yancong Zhang, Linbo Dou, Xinfeng Song, Chunyan Sun   +4 more
doaj   +1 more source

The Fate of SWCNTs in Mouse Peritoneal Macrophages: Exocytosis, Biodegradation, and Sustainable Retention

Frontiers in Bioengineering and Biotechnology, 2020
The understanding of toxicological and pharmacological profiles of nanomaterials is an important step for the development and clinical application of nanomedicines.
Ping-Xuan Dong, Ping-Xuan Dong, Xinfeng Song, Xinfeng Song, Jiwei Wu, Jiwei Wu, Shuqin Cui, Shuqin Cui, Guizhi Wang, Lianying Zhang, Hanwen Sun, Hanwen Sun   +11 more
doaj   +1 more source

Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
The aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods.
N. А. Symonenko, O. S. Shpychak, O. S. Kukhtenko, Ye. A. Bezrukavyi, H. B. Yurieva   +4 more
doaj   +1 more source

Have existing pharmaceutical excipients failed to enable oral/nasal protein delivery? [PDF]

, 2017
It seems evident that the ill-defined weltanschauung of the past decade of enabling oral un-truncated permeability-dependent protein delivery carte-blanche using existing excipients has produced sparse results.
shireesh apte
core   +2 more sources

Observational study of clinical toxicity with different formulations of docetaxel in breast cancer patients [PDF]

Farmacia Hospitalaria, 2020
Objective: To analyze the excipients and impurities contained in the various docetaxel products available on the market and find out whether they may be responsible for any of the different adverse events associated with the use of docetaxel in ...
Eva González-Haba-Peña, Margarita Garrido-Siles, María Jose Martínez-Bautista, Amparo Burgos-San José, Azucena Aldaz-Pastor, Irene Mangues-Bafalluy   +5 more
doaj   +1 more source

Different Effects of Strong-Bonded Water with Different Degrees of Substitution of Sodium Sulfobutylether-β-cyclodextrin on Encapsulation

Pharmaceutics
The encapsulation of sodium sulfobutylether-β-cyclodextrin (SBE-β-CD) is influenced not only by the degree of substitution (DS) but also by the presence of strong-bonded water (SBW).
Xiaofeng Wang, Jiaqi Huang, Dengchen Yang, Ting Huang, Yang Yang, Jiasheng Tu, Jian Zou, Huimin Sun, Xia Zhao, Rui Yang   +9 more
doaj   +1 more source