Results 21 to 30 of about 46,206 (287)

Different Effects of Strong-Bonded Water with Different Degrees of Substitution of Sodium Sulfobutylether-β-cyclodextrin on Encapsulation

Pharmaceutics
The encapsulation of sodium sulfobutylether-β-cyclodextrin (SBE-β-CD) is influenced not only by the degree of substitution (DS) but also by the presence of strong-bonded water (SBW).
Xiaofeng Wang, Jiaqi Huang, Dengchen Yang, Ting Huang, Yang Yang, Jiasheng Tu, Jian Zou, Huimin Sun, Xia Zhao, Rui Yang   +9 more
doaj   +1 more source

C35 - Formulation et fabrication des suppositoires antipaludiques d’Artémisia annua d’Ouest Cameroun en utilisant le beurre de karité comme excipient

Journal Africain de Technologie Pharmaceutique et Biopharmacie, 2023
Introduction : Le but de la présente étude est de formuler et fabriquer des suppositoires antipaludiques à base des matières premières locales (poudre de feuilles et de tiges de Artemisia annua comme principe actif et beurre de karité amélioré utilisé ...
Lionel Tematio Nague, Emmanuel Mpondo Mpondo, Emmanuel Nnanga Nga, J. S. N. Foumane Maniepi, V. Soppo Lobe, J. A. Metogo Ntsama, A. Minyem , F.C. Mbenga Mekoulou, F. Ngolsou, J. Nko’o, P. Obono, M. Nyangono Ndongo, J. Ze Minkande   +12 more
doaj   +1 more source

(Benzo[h]quinoline-κ²C,N)-[2,2′-bis(diphenylphosphino)-1,1′-binaphthalene-κ²P,P′]-platinum(II) Hexafluorophosphate

Molbank
A cyclometalated platinum(II) complex [Pt(bzq)(BINAP)]PF6 bearing a 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (BINAP) auxiliary ligand and a cyclometalated benzo[h]quinoline (bzq) ligand have been prepared.
Haoni Wang, Meiting Zhang, Jianwei Wu, Junqi Zhang, Xianglong Meng, Yuliang Yang   +5 more
doaj   +1 more source

The regulation of Pharmaceutical Excipients [PDF]

, 2016
Pharmaceutical excipients are vital components of drug formulations and are generally considered pharmacologically inert. Control of excipient manufacturing and distribution is now considered a key priority by regulatory authorities and pharmaceutical ...
Vikrant Saluja, Bhupinder Singh Sekhon
core  

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Synthesis and crystal structure of ethyl (2S,4aS,6aS,6bR,8aR,12aS,12bR,14bR,E)-10-(((3,4-dichlorobenzyl)oxy)imino)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate

Zeitschrift für Kristallographie - New Crystal Structures
C39H53Cl2NO4, monoclinic, P21 (no. 4), a = 7.55730(10) Å, b = 11.0989(2) Å, c = 20.9222(3) Å, β = 91.426(1)°, V = 1754.36(5) Å3, Z = 2, Rgt(F) = 0.0360, wRref(F2) = 0.1028, T = 169.98(10) K.
Dong Zhang-Chao, Shen Hui, Mu Ze-Bo, Xu Kai-Hua   +3 more
doaj   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

Angewandte Chemie, EarlyView.
This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong, François Bénard, David M. Perrin   +2 more
wiley   +2 more sources

What does the future hold for Pharmaceutical Excipients [PDF]

, 2017
Many of the excipients we use today have been around for more than fifty years. In many cases, the specifications for those excipients have not changed much over the years, either.
Chris Moreton
core  

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source