Results 91 to 100 of about 906,775 (316)

Excitation-Inhibition Balance: A Study of Brain Network Dynamics Using Statistical Mechanics

, 2021
The brain is a complex dynamical system whose functional properties are largely determined by the characteristics of its neurons and patterns of synaptic connectivity.
Igor Fortel (11713001)
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations

Children
Infantile spasms are common in Down Syndrome (DS), but the mechanisms by which DS predisposes to this devastating epilepsy syndrome are unclear.
Carl E. Stafstrom, Li-Rong Shao
doaj   +1 more source

Opposing effects of intrinsic conductance and correlated synaptic input on Vm-fluctuations during network activity

Frontiers in Computational Neuroscience, 2012
Neurons often receive massive concurrent bombardment of synaptic inhibition and excitation during functional network activity. This increases membrane conductance and causes fluctuations in membrane potential (Vm) and spike timing.
Jens eKolind, Jorn eHounsgaard, Rune W. Berg   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Excitation of twin-vortex flow in the nightside high-latitude ionosphere during an isolated substorm [PDF]

, 2002
We present SuperDARN radar observations of the ionospheric flow during a well-observed high-latitude substorm which occurred during steady northward IMF conditions on 2 December 1999.
Tim K. Yeoman (7583066), S. W. H. Cowley, J. B. Sigwarth, Watermann, J.F., Sigwarth, J.B., Cowley, S.W.H., Grocott, A., S.W.H. Cowley (7591226), Adrian Grocott (7590026), Watermann, J. F., T. K. Yeoman, Cowley, S. W. H., J. F. Watermann, A. Grocott, Sigwarth, J. B., Yeoman, T. K., Yeoman, T.K., J.B. Sigwarth (7591229), J.F. Watermann (7591232)   +18 more
core   +1 more source

Excited Mob

Stochastic Processes and their Applications, 2016
V2 includes minor fixes + a new section on stationary leftover ...
Amir G., Orenshtein T.
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Complex Dynamics of Propagating Waves in a Two-Dimensional Neural Field

Frontiers in Computational Neuroscience, 2019
Propagating waves with complex dynamics have been widely observed in neural population activity. To understand their formation mechanisms, we investigate a type of two-dimensional neural field model by systematically varying its recurrent excitatory and ...
Daniel Naoumenko, Pulin Gong, Pulin Gong
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source