Results 61 to 70 of about 511,304 (268)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Cascaded Voltage-Control Method for a Diode-Front-End-Based Variable-Speed Synchronous Generator in a DC Power System

open access: yesIEEE Access
This paper proposes a novel cascade voltage-control method for DC variable-speed synchronous generators with a diode rectifier. In order to emphasize the necessity of the proposed method, the light-load voltage fluctuation problem that affects the ...
Sung-Soo Min, Kyoung-Min Choo
doaj   +1 more source

Development of transverse excitation MFL inline detector

open access: yesYou-qi chuyun, 2020
A transverse excitation magnetic flux leakage (MFL) inline detector, with a diameter of 711 mm, was developed in response to the difficulty in detecting axial metal loss defects of long-distance oil and gas pipelines.
Chao YU   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Novel Flexible Excitation System Based on MultilevelTopology Technology

open access: yesZhongguo dianli, 2019
Based on the development trend of the next generation power system, a novel flexible excitation system is designed based on three-level voltage source converter, and a matching five-level DC chopping circuit is proposed.
Kuayu WU   +6 more
doaj   +1 more source

Systematic Proportional Method for Improving the Measurement Accuracy of Passive Sensor Measurement System

open access: yesIEEE Access, 2020
The accuracy and stability of excitation source determine the measurement accuracy of passive sensor measurement system, but the implementation of high-precision excitation source (especially AC excitation source) is difficult or costly in design and ...
Jintao Zhang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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