Results 81 to 90 of about 45,262,696 (341)

Independent Optical Excitation of Distinct Neural Populations

open access: yesNature Methods, 2014
Optogenetic tools enable examination of how specific cell types contribute to brain circuit functions. A long-standing question is whether it is possible to independently activate two distinct neural populations in mammalian brain tissue.
Nathan C. Klapoetke   +20 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Review of Modern Excitation Strategies for Wound Field Synchronous Motors: An Electric Vehicle Perspective

open access: yesMachines
Wound Field Synchronous Motors (WFSMs) offer precise control over the rotor magnetic field, making them well suited to electric vehicle (EV) traction applications that require adjustable excitation, wide constant-power operation, and freedom from rare ...
Pragya Raghav, Himavarsha Dhulipati
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Excitation-oriented recursive learning control

open access: yes
To address the severe dependence on the high-level persistent excitation (PE) condition and the performance deficiencies in traditional stochastic gradient descent-based neural network learning control (SGD-NNLC), which is grounded in deterministic ...
L Bin (13515985)   +5 more
core   +2 more sources

Cascaded Voltage-Control Method for a Diode-Front-End-Based Variable-Speed Synchronous Generator in a DC Power System

open access: yesIEEE Access
This paper proposes a novel cascade voltage-control method for DC variable-speed synchronous generators with a diode rectifier. In order to emphasize the necessity of the proposed method, the light-load voltage fluctuation problem that affects the ...
Sung-Soo Min, Kyoung-Min Choo
doaj   +1 more source

Design, Modeling and Experimental Validation of a Variable Resonant Electro-Hydraulic Fatigue Testing System

open access: yesIEEE Access, 2019
High frequency excitation in the electro-hydraulic mode, especially kilohertz regime, has already been realized owing to the merits of specially designed two-dimensional rotary valve (2D rotary valve).
Yan Ren, Jiping Bai, Jian Ruan
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Periodic excitations of bilinear quantum systems [PDF]

open access: yesAutomatica, 2012
A well-known method of transferring the population of a quantum system from an eigenspace of the free Hamiltonian to another is to use a periodic control law with an angular frequency equal to the difference of the eigenvalues. For finite dimensional quantum systems, the classical theory of averaging provides a rigorous explanation of this ...
openaire   +2 more sources

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