Results 221 to 230 of about 9,081,085 (259)

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Altered Excitation-Inhibition Balance and mGluR_1/5-Driven Plasticity in the Motor Cortical Surface in a Rat Model of Parkinson's Disease. [PDF]

Int J Mol Sci
Shin H, Kwon YJ, Hwang H, Ko T, Choi EB, Kim YT, Han YM, Kim JG, Zhou Q, Yang S, Yang S.   +10 more
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Fyn kinase: a key mechanistic regulator and therapeutic target in tauopathy and neurodegenerative diseases. [PDF]

Transl Neurodegener
Wang H, Fan X, Ping J, Shao Q, Wang C, Wang H, Ji Q, Su M, Qian W.   +8 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms. [PDF]

J Cell Commun Signal
Wu M, Zeng X, Cai Y, Chen H, Li Q, Yang H.   +5 more
europepmc   +1 more source

The Quest for the Associative Device for Hebbian-Like LTP-The Accidental Participant. [PDF]

Hippocampus
Gustafsson B.
europepmc   +1 more source