Suppression of hypersynchronous network activity in cultured cortical neurons using an ultrasoft silicone scaffold [PDF]
The spontaneous activity pattern of cortical neurons in dissociated culture is characterized by burst firing that is highly synchronized among a wide population of cells. The degree of synchrony, however, is excessively higher than that in cortical tissues.
arxiv +1 more source
Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia [PDF]
Little is known about the nature of the calcium channels controlling neurotransmitter release from preganglionic parasympathetic nerve fibres. In the present study, the effects of selective calcium channel antagonists and amiloride were investigated on ...
A.B Smith+33 more
core +1 more source
Background: Uremic toxins resulting from chronic kidney disease (CKD) can cause cognitive and emotional disorders, as well as cardiovascular diseases. Indoxyl sulfate (IS) and p-cresol are notable uremic toxins found in patients with CKD.
Yeon Hee Yu+6 more
doaj +1 more source
Consistency and diversity of spike dynamics in the neurons of bed nucleus of Stria Terminalis of the rat: a dynamic clamp study [PDF]
Neurons display a high degree of variability and diversity in the expression and regulation of their voltage-dependent ionic channels. Under low level of synaptic background a number of physiologically distinct cell types can be identified in most brain ...
A Bacci+34 more
core +3 more sources
Membrane resonance enables stable and robust gamma oscillations [PDF]
Neuronal mechanisms underlying beta/gamma oscillations (20-80 Hz) are not completely understood. Here, we show that in vivo beta/gamma oscillations in the cat visual cortex sometimes exhibit remarkably stable frequency even when inputs fluctuate ...
Moca, Vasile V.+3 more
core +1 more source
The majority of excitatory synapses are located on dendritic spines of cortical glutamatergic neurons. In spines, compartmentalized Ca2+ signals transduce electrical activity into specific long-term biochemical and structural changes.
Anne-Kathrin Theis+11 more
doaj +1 more source
Mimicking synaptic plasticity with wedged Pt/Co/Pt spin-orbit torque device [PDF]
We fabricated a wedge-shaped Pt/Co/Pt device with perpendicular magnetic anisotropy and manifested that the Co magnetization can be solely switched by spin-orbit torque without any magnetic field. Similar to the synaptic weight, we observed that the state of Co magnetization (presented by the anomalous Hall resistance RH) of the wedged Pt/Co/Pt device ...
arxiv +1 more source
Multi-contact synapses for stable networks: a spike-timing dependent model of dendritic spine plasticity and turnover [PDF]
Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of dendritic spine shape and volume, a correlate of synaptic strength, can be tracked in vivo for weeks.
arxiv +1 more source
Meta-Potentiation: Neuro-Astroglial Interactions Supporting Perceptual Consciousness [PDF]
Conscious perceptual processing involves the sequential activation of cortical networks at several brain locations, and the onset of oscillatory synchrony affecting the same neuronal population.
Alfredo Pereira Jr, Fá
core +2 more sources
Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex
Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) somatosensory thalamic nucleus most densely innervates layer 4 (L4 ...
B Semihcan Sermet+7 more
doaj +1 more source