Results 71 to 80 of about 72,565 (297)

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

Molecular Neurodegeneration, 2010
Background Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction.
Inestrosa Nibaldo C, Fuenzalida Marco, Bonansco Christian, Godoy Juan A, Farías Ginny G, Cerpa Waldo   +5 more
doaj   +1 more source

Effect of endogenous substance P on visceral afferent signal integration in the nucleus tractus solitaries of rat brainstem slices

IBRO Neuroscience Reports, 2023
In the first synapse of the blood-pressure-regulating pathway, a neurokinin (NK) family peptide substance P (SP) is release with an excitatory neurotransmitter, glutamate, to enhance the sensitivity of the baroreflex responses.
Zhenhua Jin, Jin-Bae Kim, Young-Ho Jin
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]

, 2000
To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz, Langosch, J., Loewenich, C. von, Walden, Jörg   +3 more
core   +1 more source

Self‐Powered Flexible Triboelectric‐Gated Ion‐Gel Transistor for Neuromorphic Tactile Sensing and Human Activity Recognition

Advanced Materials, EarlyView.
A fully flexible ion‐gel‐gated graphene‐channel transistor driven by a triboelectric nanogenerator enables self‐powered tactile sensing and synaptic learning. Mimicking spike‐rate‐dependent plasticity, the device exhibits frequency‐selective potentiation and depression, supporting rate‐coded neuromorphic computation even under flex.
Hanseong Cho, Seoyeon Park, Youngmin Lee, Sejoon Lee   +3 more
wiley   +1 more source

Voltage Gated Calcium Channel Activation by Backpropagating Action Potentials Downregulates NMDAR Function

Frontiers in Cellular Neuroscience, 2018
The majority of excitatory synapses are located on dendritic spines of cortical glutamatergic neurons. In spines, compartmentalized Ca2+ signals transduce electrical activity into specific long-term biochemical and structural changes.
Anne-Kathrin Theis, Balázs Rózsa, Balázs Rózsa, Gergely Katona, Dietmar Schmitz, Dietmar Schmitz, Dietmar Schmitz, Dietmar Schmitz, Dietmar Schmitz, Friedrich W. Johenning, Friedrich W. Johenning, Friedrich W. Johenning   +11 more
doaj   +1 more source

Neural delays shape selectivity to interaural intensity differences in the lateral superior olive [PDF]

, 1996
Neurons in the lateral superior olive (LSO) respond selectively to interaural intensity differences (IIDs), one of the chief cues used to localize sounds in space.
Grothe, Benedikt, Koch, Ursula, Park, Thomas J., Pollak, George D., Schuller, Gerd   +4 more
core   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

eLife, 2019
Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) somatosensory thalamic nucleus most densely innervates layer 4 (L4 ...
B Semihcan Sermet, Pavel Truschow, Michael Feyerabend, Johannes M Mayrhofer, Tess B Oram, Ofer Yizhar, Jochen F Staiger, Carl CH Petersen   +7 more
doaj   +1 more source

Persistent sodium current blockers can suppress seizures caused by loss of low‐threshold D‐type potassium currents: Predictions from an in silico study of Kv1 channel disorders

Epilepsia Open, 2020
Objective Ion channels belonging to subfamily A of voltage‐gated potassium channels (Kv1) are highly expressed on axons, where they play a key role in determining resting membrane potential, in shaping action potentials, and in modulating action ...
Jiaxin Du, Viktor Vegh, David C. Reutens
doaj   +1 more source