Results 81 to 90 of about 991,760 (293)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Excited States and Collectivity in 88Se

EPJ Web of Conferences, 2018
The γ decays of excited states in the very neutron-rich nucleus 88Se have been observed following the cold neutron-induced fission of 235U at the PF1B facility of the Institut Laue-Langevin (ILL), Grenoble.
Simpson G., Grachev I., Thiamova G., Ramdhane M., Sieja K., Blanc A., Jentschel M., Köster U., Mutti P., Soldner T., de France G., Ur C.A., Urban W.   +12 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Excited Charmed Baryons

EPJ Web of Conferences, 2018
A present status of experimentally observed states of excited charmed baryons is given. The classification of charmed baryons is presented, a quark model for ground states is briefly described, and the energy levels of excited states are analyzed.
Solovieva Elena
doaj   +1 more source

Puzzles of excited charm meson masses

, 2007
We attempt a comprehensive analysis of the low lying charm meson states which present several puzzles, including the poor determination of masses of several non-strange excited mesons.
A. Upadhyay, Abe, Abe, Anastassov, Anderson, Aoki, Aubert, B. Ananthanarayan, Bauer, Becirevic, Besson, Chen, Colangelo, Colangelo, Fajfer, Goity, K. Shivaraj, Li, Link, Mehen, Sunanda Banerjee, Vijande, Yao   +22 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Excited state reversal in copper iodide clusters enables 100% exciton radiation

Nature Communications
The non-radiative metallic core (MC) centered lowest excited states of most ligand-stabilized metallic clusters commonly quench radiative but high-lying ligand-centered excited states, e.g.
Yushan Meng, Chenglin Liu, Jingjing Fei, Yue Xu, Yidan Wang, Jing Zhang, Chunbo Duan, Chunmiao Han, Hui Xu   +8 more
doaj   +1 more source

Nonclassical properties of coherent states and excited coherent states for continuous spectra

, 2011
Based on the definition of coherent states for continuous spectra and analogous to photon added coherent states for discrete spectra, we introduce the excited coherent states for continuous spectra.
Hatami, M., Honarasa, G. R., Roknizadeh, R., Tavassoly, M. K.   +3 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source