Results 121 to 130 of about 1,511,368 (259)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Análisis de los Determinantes y Costos de la Informalidad en las Pequeñas Empresas: Un Estudio Empírico para el Perú. || Analysis of Determinants and Costs of Informality in Small Businesses: An Empirical Study for Peru

open access: yesRevista de Métodos Cuantitativos para la Economía y la Empresa, 2019
La informalidad en la pequeña empresa es un fenómeno ampliamente extendido en los países de Latinoamérica. En el Perú representa el 50% de las unidades empresariales, situación que supone conocer cuáles son los determinantes de esta realidad para ...
Silupu Garcés, Brenda Liz   +1 more
doaj  

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

La Escuela Rural de Utawilaya y los adventistas en el Altiplano Puneño 1898 – 1920: Precursora de la educación rural indígena peruana y Latinoamericana

open access: yesRevista Historia de la Educación Latinoamericana, 2017
La investigación sobre el desarrollo de la “Escuela Rural de Utawilaya y los Adventistas en el Altiplano puneño 1898 – 1920”, ubicada en la provincia de Puno del sur peruano, presenta como actor relevante al educador Manuel Zúñiga Camacho, fundador de ...
David Ruelas Vargas
doaj  

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