Results 111 to 120 of about 484,245 (267)

Dimensiones que conforman el riesgo de exclusión en el sistema de transporte en la ciudad de Cali, Colombia

open access: yesCuadernos de Administración, 2015
Los sistemas informales de transporte se han convertido en la manera para encaminar las necesidades insatisfechas de transporte de la población. Se ha encontrado que hay una fuerte relación entre informalidad laboral y situaciones de exclusión social ...
Henry A. Mosquera Abadía
doaj  

El aislamiento social como supuesto articulador de las teorías sobre la exclusión y el sinhogarismo: críticas y aportes etnográficos

open access: yesCUHSO
El objetivo del artículo es discutir con el supuesto del aislamiento social en tanto eje articulador de las teorías sobre la exclusión social en general, y de los modelos de análisis sobre quienes se ven forzados a residir en la vía pública en ...
Santiago Bachiller
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Academically intelligent LLMs are not necessarily socially intelligent [PDF]

open access: yesarXiv
The academic intelligence of large language models (LLMs) has made remarkable progress in recent times, but their social intelligence performance remains unclear. Inspired by established human social intelligence frameworks, particularly Daniel Goleman's social intelligence theory, we have developed a standardized social intelligence test based on real-
arxiv  

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Score-based Generative Diffusion Models for Social Recommendations [PDF]

open access: yesarXiv
With the prevalence of social networks on online platforms, social recommendation has become a vital technique for enhancing personalized recommendations. The effectiveness of social recommendations largely relies on the social homophily assumption, which presumes that individuals with social connections often share similar preferences.
arxiv  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

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