Results 81 to 90 of about 7,874,399 (296)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Social Exclusion among Peers: The Role of Immigrant Status and Classroom Immigrant Density
Journal of Youth and Adolescence, 2016 Increasing immigration and school ethnic segregation have raised concerns about the social integration of minority students. We examined the role of immigrant status in social exclusion and the moderating effect of classroom immigrant density among ...
Stephanie M Plenty, Jan O. Jonsson
semanticscholar +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Pobreza y exclusión social como formas de violencia estructural: la lucha contra la pobreza y la exclusión social es la lucha por la paz [PDF]
, 1997 María Asunción Martínez Román
openalex +1 more source
The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study
Scientific Reports, 2017 Suicidal behaviors result from a complex interaction between social stressors and individual vulnerability. However, little is known of the specific neural network supporting the sensitivity to social stressors in patients at risk of suicidal acts. Using
E. Olié +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Nóesis, 2016 El presente artículo analiza la situación de exclusión social que viven actualmente mujeres indígenas rurales trabajadoras domésticas en el espacio urbano de Mérida Yucatán.
Rebelín Echeverría Echeverría
doaj
Recensión: Terapia ocupacional y exclusión social
Revista Chilena de Terapia Ocupacional, 2015 Frank Kronenberg propone en el prólogo del texto Terapia Ocupacional y Exclusión Social de Navarrete, Cantero, Guajardo, Sepúlveda y Moruno (2015) diferentes posibilidades y cuestionamientos respecto a la terapia ocupacional (en adelante TO).
Rodolfo Morrison
doaj +1 more source
Iniciativa ciudadana por una carta de derechos sociales contra el paro y la exclusión social [PDF]
, 1999 Juan Hernández Zubizarreta
openalex +1 more source