Results 101 to 110 of about 4,057,435 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Designing and delivering inclusive heritage tours: Good practices for engaging socially excluded audiences

open access: yesTourism
People who experience social exclusion often face barriers to participation in recreation and tourism and tend to have limited engagement with culture and heritage. Yet, both sets of activities have been linked to a range of positive outcomes.
Lynn Minnaert
doaj   +1 more source

Nationalism and the rhetoric of exclusion [PDF]

open access: yes, 2002
The late twentieth-century Serbian nationalist discourse is seen as a manifestation of the same rhetoric which was initially formulated in the period of national awakening associated with the two uprisings against the Turkish rule under Karađorđe ...
Mikula, M
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

New Exclusion for Children with Special Needs Case Study in Inclusive School in Banyumas Regency

open access: yesYinyang: Jurnal Studi Islam, Gender dan Anak
Inclusive education implemented in Banyumas Regency has attempted to provide opportunities for children with special needs to get education together with other students.
Aan Desta Riani   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

HACKING THE CITY A SOMEWHAT DIFFERENT MODE OF FIELD WORK

open access: yesEuropean Journal of Geography, 2012
Guerilla Gardening, Reclaim the street, Adbusting and others are characteristic forms of temporary appropriation of public spaces. Those have become a global trend.
Romy HOFMANN, Martina MEHREN
doaj  

Finite-dimensional approximation for the diffusion coefficient in the simple exclusion process

open access: yes, 2006
We show that for the mean zero simple exclusion process in $\mathbb {Z}^d$ and for the asymmetric simple exclusion process in $\mathbb{Z}^d$ for $d\geq3$, the self-diffusion coefficient of a tagged particle is stable when approximated by simple exclusion
Jara, Milton
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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