Results 51 to 60 of about 190,541 (353)

Reflection on Exclusivity and Termination of Commercial Agency in Jordan: TheIntertwining of Domestic Regulation and International Trade Law [PDF]

open access: yes, 2019
Any foreign manufacturer desiring to market its products in Jordan has several courses open to it. The foreign manufacturer could establish a branch or wholly-owned subsidiary in Jordan or enter into a licensing or joint venture agreement with a company ...
Malkawi, Bashar H.
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

EXCLUSION AND EXCLUSIVITY IN PROPERTY LAW [PDF]

open access: yesUniversity of Toronto Law Journal, 2008
In this article, I propose a model for understanding the concept of ownership that I call the ‘exclusivity model.’ Like many of the contemporary critics of the ‘bundle of rights’ approach to ownership, I insist that ownership is a legal concept with a well-defined structure. I differ from most of them, however, in the model of ownership that I believe
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

“Exclusivity” and quantifier float in bakari [version 2; peer review: 3 approved, 1 approved with reservations]

open access: yesF1000Research, 2022
This paper presents a descriptive study that analyzes the semantic meaning of toritate focus particle bakari. It has been pointed out that while bakari expresses exclusivity, it seemingly possesses the characteristic of allowing non-applicable cases ...
Yoshiko Numata   +3 more
doaj   +1 more source

Mutual Exclusivity Loss for Semi-Supervised Deep Learning

open access: yes, 2016
In this paper we consider the problem of semi-supervised learning with deep Convolutional Neural Networks (ConvNets). Semi-supervised learning is motivated on the observation that unlabeled data is cheap and can be used to improve the accuracy of ...
Javanmardi, Mehran   +2 more
core   +1 more source

Authorized Generic Entry prior to Patent Expiry: Reassessing Incentives for Independent Generic Entry [PDF]

open access: yes, 2010
Patent holders frequently attempt to mitigate the loss of monopoly power by authorizing generic entry prior to patent expiry (early entry). Competition in off-patent pharmaceutical markets may be adversely affected if early entry substantially impairs ...
Appelt, Silvia
core   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

The Universal Light, or the Only Way to the Father? Universalism and Exclusivism in John’s Provocative Christology

open access: yesReligions
Among the most perplexing of John’s theological riddles is question of salvific universalism and particularity. John is both the greatest biblical source of Christian universalism and the greatest source of Christian exclusivity. After all, the Johannine
Paul N. Anderson
doaj   +1 more source

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