Results 111 to 120 of about 423,800 (304)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia

open access: yes, 2013
Paul Winston Tetteh,1,4 Charles Antwi-Boasiako,1 Ben Gyan,3 Daniel Antwi,1 Festus Adzaku,1 Kwame Adu-Bonsaffoh,1,2 Samuel Obed21Department of Physiology, 2Department of Obstetrics and Gynecology, University of Ghana Medical School, Accra, Ghana ...
Adu-Bonsaffoh K   +6 more
core  

Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications

open access: yes, 2004
The efficiency of carbon conversion to biomass and desirable end products in industrial fermentations is diminished by the diversion of carbon to acetate and lactate excretions.
El-Mansi, Mansi
core   +1 more source

Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]

open access: yes, 1984
The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter   +3 more
core   +1 more source

Mass balance, metabolic disposition, and pharmacokinetics of a single IV dose of [14C]CA102N in HT-29 xenograft athymic nude mice

open access: yesFrontiers in Pharmacology
IntroductionCA102N is a novel anticancer drug developed by covalently linking H-Nim (N-(4-Amino-2-phenoxyphenyl methanesulfonamide) to Hyaluronic Acid to target CD44 receptor-rich tumors.
Eskouhie Tchaparian   +7 more
doaj   +1 more source

Phosphorus flux by macrobenthic invertebrates in a shallow eutrophic lake Donghu: spatial change

open access: yesKnowledge and Management of Aquatic Ecosystems, 2011
We estimated phosphorus flux mediated by benthic invertebrates from the sediments to the water in a shallow eutrophic lake (lake Donghu, central China) and quantified spatial (littoral and central sites) and specific (among different ...
Ji L.   +7 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

System Level Economic Analysis of Swine Diet Modifications [PDF]

open access: yes
Experimental data from low nitrogen and phosphorus diets (Carter et al, 1999, 2000, 2003) are being used to validate and/or modify the NRC swine growth model.
Stoecker, Arthur L., Lin, Yi-Hung
core  

Excretion rate of

open access: yes, 2009
Knowledge of excretion rates of naturally occurring 210Po in non-exposed people is a prerequisite for assessment of potential internal contamination with polonium.
H. Straková, Z. Hölgye
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

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