Results 91 to 100 of about 423,800 (304)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The feeding and excretion rates of Aphis Fabae Scop. on Vicia Faba L

open access: yes, 1959
The feeding and excretion rates of nymphs of Aphis fabae, feeding on young leaves of Vicia faba, were studied, using host plants grown in water culture and made radioactive with 32P.
Banks, C. J.   +3 more
core   +1 more source

A Systematic Study of the Hepatic–Intestinal First-Pass Effect and Excretion Pathways of Punicalagin Based on UPLC-MS/MS

open access: yesMolecules
Punicalagin, the major polyphenol in pomegranate peel, shows broad bioactivity but suffers from poor oral bioavailability. Whether hepatic or intestinal first-pass processes dominate this limitation remains unresolved. We developed a quantitative UPLC-MS/
Zixin Chen   +3 more
doaj   +1 more source

Effects of supplemental phytase on nutrient excretion and retention in broilers fed different cereal based diets

open access: yesCzech Journal of Animal Science, 2005
A 21-day experiment with day-old broilers was conducted in order to assess the effect of phytase supplementation to different cereals-soybean meal based diets on nitrogen, calcium, total and phytate phosphorus excretion and retention.
J. Pintar   +5 more
doaj   +1 more source

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

open access: yesPharmacology Research & Perspectives, 2020
The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA ...
Ali R. Banijamali   +10 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

STEROID EXCRETION OF INFANTS

open access: yes, 1950
The urinary excretion of corticosteroids and ketosteroids was measured in infants during the first week of life and at four and 18 months of age. It was found that corticosteroid excretion increased with age while the excretion of ketosteroids declined ...
W. F. Perry, H. Chochinov
core   +1 more source

Impact of Naturally Contaminated Substrates on Alphitobius diaperinus and Hermetia illucens: Uptake and Excretion of Mycotoxins

open access: yesToxins, 2019
Insects are considered a suitable alternative feed for livestock production and their use is nowadays regulated in the European Union by the European Commission Regulation No. 893/2017.
Giulia Leni   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Renal nerves and catecholamine excretion

open access: yes, 1981
To determine which neurotransmitters are released into urine by renal nerves, we either acutely denervated one kidney or stimulated renal nerves by activation of the baroreflex. Acute denervation increased dopamine (DA) and decreased norepinephrine (NE)
N. Morgunov, A. D. Baines
core   +1 more source

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