Results 71 to 80 of about 423,800 (304)

Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation. [PDF]

open access: yes, 2013
Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently ...
Berthold Koletzko (144194)   +36 more
core   +2 more sources

Inhibition of P-Glycoprotein Asymmetrically Alters the In Vivo Exposure Profile of SGC003F: A Novel Guanylate Cyclase Stimulator

open access: yesPharmaceuticals
As a novel guanylate cyclase stimulator, SGC003F is being developed for the treatment of heart failure with a reduced ejection fraction (HFrEF). This study aimed to assess the effect of P-glycoprotein (P-gp) inhibition on SGC003F exposure in vivo ...
Jinle Lou   +8 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension [PDF]

open access: yes, 2010
Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension.
Zanchetti A   +591 more
core   +4 more sources

Microplastic size matters for absorption and excretion by Artemia salina and Acipenser ruthenus larvae in models of water pollution and food chain transfer

open access: yesActa Biologica Sibirica
Microplastics pervade the hydrosphere and inevitably come into contact with aquatic organisms. The study reports quantitative data on absorption and excretion of polystyrene microspheres 2 and 10 µm in diameter by zooplankton and fish larvae on the ...
Yulia A. Frank   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPACT OF HYPERBARIC OXYGENATION ON RENAL AMMONIA EXCRETION DURING EXPERIMENTAL LIVER RESECTION

open access: yesОбщая реаниматология, 2015
Objective: to study the impact of hyperbaric oxygenation (HBO) on renal ammonia excretion during liver resection (LR). Material and methods. Experiments were carried out on 138 pubescent rats (females).
P. N. Savilov, D. V. Molchanov
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Meta-Analysis of Pharmacokinetic Studies of Nanobiomaterials for the Prediction of Excretion Depending on Particle Characteristics

open access: yesFrontiers in Bioengineering and Biotechnology, 2019
The growth in development and use of nanobiomaterials (NBMs) has raised questions regarding their possible distribution in the environment. Because most NBMs are not yet available on the market and exposure monitoring is thus not possible, prospective ...
Marina Hauser, Bernd Nowack
doaj   +1 more source

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