Results 51 to 60 of about 337,234 (319)
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Accurate ADMET Prediction with XGBoost [PDF]
arXiv, 2022 The absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties are important in drug discovery as they define efficacy and safety. In this work, we applied an ensemble of features, including fingerprints and descriptors, and a tree-based machine learning model, extreme gradient boosting, for accurate ADMET prediction.
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Delayed Hard Photons from Gamma-Ray Bursts [PDF]
, 1994 The delayed hard (up to 25 GeV) photons observed more than an hour following a gamma-ray burst on February 17, 1994 may result from the collisions of relativistic nucleons with a dense cloud, producing $\pi^0$. The required cloud density is $\sim 2 \times 10^{11}$ cm$^{-3}$. This cloud may be the remains of the disrupted envelope of a neutron star, and
arxiv +1 more source
Binary Stellar Mergers with Marginally-Bound Ejecta: Excretion Disks, Inflated Envelopes, Outflows, and their Luminous Transients [PDF]
MNRAS (2016), 461, 2527, 2016 We study mass loss from the outer Lagrange point (L2) in binary stellar mergers and their luminous transients by means of radiative hydrodynamical simulations. Previously, we showed that for binary mass ratios 0.06 < q < 0.8, synchronous L2 mass loss results in a radiatively inefficient, dust-forming unbound equatorial outflow. A similar outflow exists
arxiv +1 more source
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats
Frontiers in Pharmacology, 2021 Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects.
Xinchi Feng +5 more
doaj +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source