Results 51 to 60 of about 1,348,181 (298)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

ERP evidence suggests executive dysfunction in ecstasy polydrug users [PDF]

, 2013
Background: Deficits in executive functions such as access to semantic/long-term memory have been shown in ecstasy users in previous research. Equally, there have been many reports of equivocal findings in this area.
A Gamma, A Miyake, A Pazos, AC Parrott, AG Verstraete, AJ Saykin, AP Burgess, B Kopp, C Casco, C Montgomery, C Montgomery, C Montgomery, C Montgomery, C Montgomery, C Whitney, C. A. Roberts, C. Montgomery, D Badre, D Davison, DE Hinkle, DM McDowell, DT Stuss, E Jefferies, EM Bekker, F. Tames, G Jager, G Kanayama, HC Fox, J Cole, J. E. Fisk, JA Horne, JE Fisk, JH Halpern, JR Folstein, M Terman, MA Wetherell, MJ Morgan, N Yeung, PN Murphy, RL Carhart-Harris, RM Ruff, RM Shiffrin, S Bhattachary, S Mejias, S Nieuwenhuis, S Rossi, S Sola de, S Suwazono, S. H. Fairclough, SJ Luck, SL Rosell, T Akerstedt, V Veen van, W Ritter   +53 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Complex PTSD symptom clusters and executive function in UK Armed Forces veterans: a cross-sectional study

BMC Psychology
Background Less is known about complex posttraumatic stress disorder (CPTSD) than postrraumatic stress disorder (PTSD) in military veterans, yet this population may be at greater risk of the former diagnosis. Executive function impairment has been linked
Natasha Biscoe, Emma New, Dominic Murphy
doaj   +1 more source

Naturally occurring circadian rhythm and sleep duration are related to executive functions in early adulthood [PDF]

, 2017
Experimental sleep deprivation studies suggest that insufficient sleep and circadian misalignment associates with poorer executive function. It is not known whether this association translates to naturally occurring sleep patterns. A total of 512 of full-
Banks, Bin, Bjorkqvist, Bohnen, Bratzke, Cain, Conners, Cotrena, Day, De Souza, Digdon, Dixit, Duffy, Friedman, Gobin, Hahn, Heinonen, Jackson, Juda, Lemola, Lo, Moeller, Pesonen, Pyhala, Reitan, Riegel, Rossa, Roth, Rowe, Rutters, Salthouse, Shields, Tangney, Toplak, Vartanian, Whiting, Wilckens, Wittmann, Wolke, Wong   +39 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The impact of fathers’ involvement on preschoolers’ resilience: a moderated mediation model

BMC Psychology
Objective This study based on the Kumpfer’s resilience framework, examines the relationship between fathers’ involvement and preschoolers’ resilience, focusing on the mediating role of preschoolers’ executive function and the moderating role of ...
Haiyan Cui, Yucai Xiong, Jiajia Gong, Jinghui Zhao   +3 more
doaj   +1 more source

Altered Executive Function in Suicide Attempts

European Psychiatry, 2022
Introduction Executive function organizes and directs behaviour but alterations in this cognitive domain can lead to inaccurate perception, interpretation and response to environmental information, which could be a risk factor for suicide.
J. Fernández, S. Alberich, I. Zorrilla, I. González-Ortega, M.P. López, V. Pérez-Solà, E. Vieta, A.M. González-Pinto, P.A. Saiz   +8 more
doaj   +1 more source

Processing speed, executive function, and age differences in remembering and knowing. [PDF]

, 2004
A group of young (n = 52, M = 23.27 years) and old (n = 52, M = 68.62 years) adults studied two lists of semantically unrelated nouns. For one list a time of 2 s was allowed for encoding, and for the other, 5 s.
Bunce, D, Macready, A
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source