Results 61 to 70 of about 1,361,633 (327)

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults. [PDF]

, 2018
Diet may be an important modifiable risk factor for maintenance of cognitive health in later life. This study aimed at examining associations between common dietary indices and dietary patterns defined by factor analysis and cognitive function in older ...
Barrett-Connor, Elizabeth, Kritz-Silverstein, Donna, Laughlin, Gail A, McEvoy, Linda K, Reas, Emilie T, Richard, Erin L   +5 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Effects of a multicomponent exercise on dual-task performance and executive function among older adults

International Journal of Gerontology, 2018
Summary: Background: Previous studies showed that multicomponent exercise enhanced physical and cognitive functions. This study aimed to investigate the effects of a multicomponent exercise on dual-task performance and executive function and to ...
Ray-Yau Wang, Yuan-Li Wang, Fang-Yu Cheng, Yuan-Hung Chao, Chien-Liang Chen, Yea-Ru Yang   +5 more
doaj   +1 more source

Processing speed, executive function, and age differences in remembering and knowing. [PDF]

, 2004
A group of young (n = 52, M = 23.27 years) and old (n = 52, M = 68.62 years) adults studied two lists of semantically unrelated nouns. For one list a time of 2 s was allowed for encoding, and for the other, 5 s.
Bunce, D, Macready, A
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The impact of executive function on stress, difficulties, and teaching behaviours of pre-service teachers on their first practicum placement

International Journal of Educational Research Open
This article describes the impact of executive function on pre-service teachers’ experiences during their first practicum placement, with a focus on the key stressors and their perceptions of difficulties.
Jeffrey William Harris MacCormack, Charlotte Ann Brenner   +1 more
doaj   +1 more source

The Association Between Work-Related Rumination and Executive Function Using the Behavior Rating Inventory of Executive Function

Frontiers in Psychology, 2020
Work-related rumination has been associated with a number of health complaints, however, little is known about the underlying factors associated with rumination.
Mark Cropley, Hannah Collis
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Prospective memory functioning among ecstasy/polydrug users: evidence from the Cambridge Prospective Memory Test (CAMPROMPT) [PDF]

, 2011
Rationale: Prospective memory (PM) deficits in recreational drug users have been documented in recent years. However, the assessment of PM has largely been restricted to self-reported measures that fail to capture the distinction between event-based and
A Costa, A Miyake, A Rey, BA Wilson, BA Wilson, BG Tabachnick, C Montgomery, C Montgomery, C Montgomery, C Thompson, Catharine Montgomery, CC Adda, D Tomasi, DM Spooner, F Hadjiefthyvoulou, Florentia Hadjiefthyvoulou, HC Fox, HG Pope Jr, J Fleming, J Okuda, J Raven, J Rodgers, J Rodgers, JD Henry, JE Fisk, JE Fisk, John E. Fisk, JR Crawford, JR Leitz, KL Medina, L Reneman, L Reneman, M Kliegel, MA McDaniel, N Solowij, Nikola Bridges, PG Rendell, PG Rendell, PG Rendell, PN Murphy, PW Burgess, R Hannon, RA Dixon, RL Marsh, RM Roth, S McHale, SJ Gilbert, T Martin, T Paraskevaides, TM Heffernan, TM Heffernan, Y Goto, YCT Groot   +52 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source