Results 71 to 80 of about 1,361,633 (327)

Longitudinal evaluation of cognitive functioning in young children with type 1 diabetes over 18 months [PDF]

, 2016
OBJECTIVE: Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T1D. METHODS: 144
Ambrosino, Jodie, Aye, Tandy, Beck, Roy W, Cato, M. Allison, Cheng, Peiyao, Hershey, Tamara, Kollman, Craig, Mauras, Nelly, Mazaika, Paul, Reiss, Allan L, Ruedy, Katrina J, Tansey, Michael, White, Neil H   +12 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Repeatability and validity of a food frequency questionnaire in free-living older people in relation to cognitive function [PDF]

, 2008
Objectives: To determine the repeatability and validity of a self-administered, 175-item food frequency questionnaire (FFQ) in free-living older people and to assess whether these are influenced by cognitive function.
Aucott, Lorna S, Craig, Leone CA, Jia, Xueli, McNeill, Geraldine, Milne, Anne C   +4 more
core  

ERP evidence suggests executive dysfunction in ecstasy polydrug users [PDF]

, 2013
Background: Deficits in executive functions such as access to semantic/long-term memory have been shown in ecstasy users in previous research. Equally, there have been many reports of equivocal findings in this area.
A Gamma, A Miyake, A Pazos, AC Parrott, AG Verstraete, AJ Saykin, AP Burgess, B Kopp, C Casco, C Montgomery, C Montgomery, C Montgomery, C Montgomery, C Montgomery, C Whitney, C. A. Roberts, C. Montgomery, D Badre, D Davison, DE Hinkle, DM McDowell, DT Stuss, E Jefferies, EM Bekker, F. Tames, G Jager, G Kanayama, HC Fox, J Cole, J. E. Fisk, JA Horne, JE Fisk, JH Halpern, JR Folstein, M Terman, MA Wetherell, MJ Morgan, N Yeung, PN Murphy, RL Carhart-Harris, RM Ruff, RM Shiffrin, S Bhattachary, S Mejias, S Nieuwenhuis, S Rossi, S Sola de, S Suwazono, S. H. Fairclough, SJ Luck, SL Rosell, T Akerstedt, V Veen van, W Ritter   +53 more
core   +1 more source

Serum glial cell line-derived neurotrophic factor (GDNF) a potential biomarker of executive function in Parkinson’s disease [PDF]

, 2023
Shuyan Tong, Rui-Wen Wang, Qian Li, Yi Liu, Xiaoyan Yao, Deqin Geng, Dianshuai Gao, Chao Ren   +7 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Speech-in-speech perception and executive function involvement. [PDF]

PLoS ONE, 2017
This present study investigated the link between speech-in-speech perception capacities and four executive function components: response suppression, inhibitory control, switching and working memory. We constructed a cross-modal semantic priming paradigm
Marcela Perrone-Bertolotti, Maxime Tassin, Fanny Meunier   +2 more
doaj   +1 more source

Resting state connectivity and cognitive performance in adults with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy [PDF]

, 2016
Cognitive impairment is an inevitable feature of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), affecting executive function, attention and processing speed from an early stage.
Cullen, Breda, Kalladka, Dheeraj, Krishnadas, Rajeev, López-González, Maria R., Moreton, Fiona C., Muir, Keith W., Santosh, Celestine, Schwarzbauer, Christian, Stringer, Michael S.   +8 more
core   +1 more source

Does Executive Function Training Impact on Communication? A Randomized Controlled tDCS Study on Post-Stroke Aphasia [PDF]

, 2022
Francesca Pisano, Alessio Manfredini, Andrea Castellano, Carlo Caltagirone, Paola Marangolo   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source