Results 71 to 80 of about 11,677,620 (399)

Is intelligence equivalent to executive functions?

Psicothema, 2018
BACKGROUND Since the mid 19th century, cognitive and behavioral neurosciences have attempted to find the neurological bases of intellectual abilities. During the early 20th century the psychometric concept of "intelligence" was coined; and toward the end
A. Ardila
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Executive functions in insomnia disorder: a systematic review and exploratory meta-analysis [PDF]

, 2019
Background: Executive functions (EFs) are involved in the control of basic psychological processes such as attention and memory and also contribute to emotion regulation.
Aquino, Maria Raisa Jessica V., Ballesio, Andrea, Ferlazzo, Fabio, Kyle, Simon D., Lombardo, Caterina   +4 more
core   +3 more sources

Relationships between Motor and Executive Functions and the Effect of an Acute Coordinative Intervention on Executive Functions in Kindergartners

Frontiers in Psychology, 2017
There is growing evidence indicating positive, causal effects of acute physical activity on cognitive performance of school children, adolescents, and adults. However, only a few studies examined these effects in kindergartners, even though correlational
M. Stein, Max Auerswald, M. Ebersbach
semanticscholar   +1 more source

Imaging the genetics of executive function [PDF]

Biological Psychology, 2008
Recent advances in neuroimaging technologies have allowed ever more detailed studies of the human brain. The combination of neuroimaging techniques with genetics may provide a more sensitive measure of the influence of genetic variants on cognitive function than behavioural measures alone.
Greene, C. M., Braet, W., Johnson, K. A., Bellgrove, M. A.   +3 more
openaire   +6 more sources

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Consent for further education colleges to invest in companies [PDF]

, 2011
Summary: This guidance document is aimed at college principals and finance directors as well as staff within the Skills Funding Agency. It lays out the requirements for Further Education (FE) colleges to seek Skills Funding Agency (the Agency) consent to

core  

The influence of fluid intelligence, executive functions and premorbid intelligence on memory in frontal patients [PDF]

, 2018
It is commonly thought that memory deficits in frontal patients are a result of impairments in executive functions which impact upon storage and retrieval processes.
Aizpurua, Alexander, Baddeley, Baldo, Baldo, Barbey, Baudic, Benton, Buckner, Buckner, Cipolotti, Cipolotti, Cipolotti, Cipolotti, Crawford, della Rocchetta, Duncan, Gallistel, Gershberg, Janowsky, Jeffreys, Keifer, Kopelman, MacPherson, MacPherson, MacPherson, McKenna, Milner, Nelson, Raven, Roca, Stuss, Trenerry, Troyer, Turner, Warrington, Warrington, Wheeler, Woolgar   +38 more
core   +4 more sources