Results 61 to 70 of about 979,425 (244)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The Utility of Angular Velocity During Back Squat to Predict 1RM and Load–Velocity Profiling

Sensors
Linear velocity is commonly used to estimate 1-repetition maximum (1RM) from a load–velocity profile (LVP), as well as prescribe training intensity. However, no study has assessed angular velocity, which may be more representative of joint motion.
Kyle S. Beyer, Jonathan P. Klee, Jake C. Ojert, Marco D. Grenda, Joshua O. Odebode, Steve A. Rose   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sexual dimorphism in the serum metabolome following acute exhaustive exercise

Biology of Sex Differences
Background Sex differences in exercise metabolism have been recognized for decades, but the molecular metabolic landscape in which men and women reach standardized physiological exhaustion criteria remains unexplored.
Baile Wu, Chunxue Tang, Zhongxun Ren, Jiayu Qian, Yuxiao Deng, Zihan Fan, YanYan Zhang, Lijun Shi   +7 more
doaj   +1 more source

Nutritional status and practices among Chinese marathon runners: data from the China marathon nutrition survey (CMNS)

Journal of the International Society of Sports Nutrition
Background The increasing popularity of marathon running in China highlights the need to better understand the dietary habits and nutritional needs of marathon runners to optimize performance and health outcomes.
Yan Chen, Xueyuan Zhao, Xiangxin Li, Wei Wen, Jingyi Zhang, Zhihui Lu, Yiheng Liang, Chengnan Zhang, Junqiang Qiu   +8 more
doaj   +1 more source

Increased throwing accuracy improves children’s catching performance in a ball-catching task from the movement assessment battery (MABC-2)

Frontiers in Psychology, 2016
The Movement Assessment Battery for Children (MABC-2) is a functional test for identifying deficits in the motor performance of children. The test contains a ball-catching task that requires the children to catch a self-thrown ball with one hand.
Tim Dirksen, Marc H.E. De Lussanet, Karen Zentgraf, Lena Slupinski, Heiko Wagner   +4 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The effect of chronic soluble keratin supplementation in physically active individuals on body composition, blood parameters and cycling performance

Journal of the International Society of Sports Nutrition, 2018
Background Keratins are structural, thiol-rich proteins, which comprise 90% of total poultry feather weight. Their favourable amino acid profile suggests the potential for use as a protein source and ergogenic aid for endurance athletes, following ...
Emma M. Crum, Yanita D. McLeay, Matthew J. Barnes, Stephen R. Stannard   +3 more
doaj   +1 more source