Results 111 to 120 of about 7,733,951 (272)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Unity Movement : principles and policy

A document in which the principles and policies of the Unity Movement are stated: non-collaboration, non-racialism, one nation, anti-imperialism, minimum demands, the working ...
Unity Movement
core  

Application of YOLO11 and Long Short-Term Memory Architecture for Exercise Form Evaluation in Weightlifting

Jurnal Teknologi dan Manajemen Informatika
Exercise provides significant benefits for physical health, and weightlifting has become increasingly popular among fitness enthusiasts. However, improper lifting techniques often lead to injuries, discouraging beginners and affecting long-term training ...
Nicholas Dylan Lienardi, Evan Tanuwijaya
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Efecto de la movilización articular sobre la amplitud del Reflejo H en personas con espasticidad

Revista Ciencias de la Salud, 2011
Objective: To determine the effect of ankle joint mobilization on the H reflex amplitude of the soleus muscle in people with spasticity. Materials and methods: A quasi-experimental study with crossover design and simple masking was conducted in 24 ...
Julio Ernesto Pérez Parra, Claudia Patricia Henao Lema   +1 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Evidence for the Fast Exercise Drive to Breathe During Sinusoidal Cycle Ergometry [PDF]

, 2014
Human experimentation investigating the role of limb movement frequency on the fast exercise drive to breathe has not reached agreement on the mechanism that produces this response.
Caterini, Elizabeth Jessica
core   +1 more source

Using the behavior change wheel to design a novel home‐based exercise program for adults living with overweight and obesity: Comprehensive reporting of intervention development

Obesity Science & Practice
Introduction Physical activity and exercise are movement behaviors that support the lifestyle management of overweight and obesity. However, home‐based exercise programs are commonly generic, and inconsistently undertake a holistic approach to program ...
Sofie Power, David Broom, Michael Duncan, Stuart Biddle, Nikita Rowley   +4 more
doaj   +1 more source