Results 121 to 130 of about 3,646,791 (298)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Knowledge, attitude, and practice of stroke patients' family members towards stroke rehabilitation: A cross-sectional study

Journal of Stroke and Cerebrovascular Diseases
Background: This study aimed to explore the knowledge, attitude, and practice (KAP) among family members of stroke patients regarding stroke rehabilitation.
Dongdong Li, Hui Guo, Yiwen Sun, Zhijun Zhang, Huilin Liu   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity

Scientific Reports
Altitude training is a method among endurance athletes to enhance performance via hypoxia-induced adaptations. However, individual responses vary significantly, with some athletes even showing performance decrements.
Svenja Nolte, Deeksha Malhan, Anna Klemmer, Tom Kastner, Nico Walter, Daniel Fleckenstein, Johannes Keck, Simon Klügel, Celina Maier, Kristina Gebhardt, Tobias Stauber, Angela Relógio, Karsten Krüger, Karsten Hollander   +13 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effect of walkability on the physical activity of hemodialysis patients: a multicenter study

Renal Replacement Therapy
Introduction Physical activity is an important prognostic factor in patients undergoing hemodialysis. Walkability also affects physical activity. This study aimed to examine the effects of walkability on the physical activity of patients undergoing ...
Yoichi Sato, Naoto Usui, Yoshifumi Abe, Daisuke Okamura, Yota Kuramochi, Sho Kojima, Nobuto Shinozaki, Yu Shimano, Nobuyuki Shirai, Kenta Mikami, Yoji Yamada, Masakazu Saitoh   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effects of Exercise Therapy on Gait Ability and Quality of Life Patients with Chronic Venous Insufficiency: A Systematic Review and Meta-Analysis

Purpose: This study was conducted to quantitatively investigate the effects of exercise therapy on gait ability and quality of life (QoL) in patients with chronic venous insufficiency (CVI) through a systematic review and meta-analysis.Methods: A ...
Korea Exercise Rehabilitation Welfare Association, Sang-Kyu Bae, Bong-Hyun Lee   +2 more
core   +1 more source