Results 141 to 150 of about 3,646,791 (298)

Reliability of ratings of perceived exertion during progressive treadmill exercise. [PDF]

, 1999
This is the author's PDF of an article published in British journal of sports medicine© 1999. The definitive version is available at http://bjsm.bmj.comOBJECTIVE: To assess the test-retest reliability (repeatability) of Borg's 6-20 rating of perceived ...
Lamb, Kevin L., Corns, David, Eston, Roger   +2 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Examining Compliance, Barriers and Facilitators to Ongoing Aquatic Exercise Post Discharge from Hospital Outpatient Aquatic Therapy

, 2009
Purpose: The purpose of this study was to determine the level of compliance with a continued aquatic exercise program following discharge from a limited hospital outpatient aquatic service, and to discover patient perceptions of the barriers and ...
Haines, Terry, Cornwell, Petrea, Phillpotts, Wendy   +2 more
core  

Maximal strength training improves muscle-tendon properties and increases tendon matrix remodulation in well-trained triathletes

Scientific Reports
This study assessed the effects of a 12-week strength training (ST) intervention on Achilles and patellar tendon stiffness and tendon-matrix blood-borne markers in well-trained triathletes performing concomitant high-volume aerobic training.
Mats W. Jacobs, Joshua F. Feuerbacher, Falk Mersmann, Wilhelm Bloch, Adamantios Arampatzis, Moritz Schumann   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Neutral Protamine Hagedorn (NPH) insulin attenuates memory impairments in diabetic rats

Diabetology & Metabolic Syndrome
Cognitive decline is a significant complication of type 1 diabetes (T1D) that substantially affects patients' quality of life. Although previous studies suggest that Neutral Protamine Hagedorn (NPH) insulin may mitigate certain effects of streptozotocin ...
Marcelo T. Andrade, Camila B. Gomes, Débora O. Fernandes, Bruno P. Melo, Michele M. Moraes, Ana F. S. Almeida, Laura F. J. Alvarado, Grace S. Pereira, Juliana B. Guimarães, Elsa Heyman, Romain Meeusen, Thiago T. Mendes, Danusa D. Soares   +12 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source