Results 151 to 160 of about 989,646 (311)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Neutral Protamine Hagedorn (NPH) insulin attenuates memory impairments in diabetic rats

Diabetology & Metabolic Syndrome
Cognitive decline is a significant complication of type 1 diabetes (T1D) that substantially affects patients' quality of life. Although previous studies suggest that Neutral Protamine Hagedorn (NPH) insulin may mitigate certain effects of streptozotocin ...
Marcelo T. Andrade, Camila B. Gomes, Débora O. Fernandes, Bruno P. Melo, Michele M. Moraes, Ana F. S. Almeida, Laura F. J. Alvarado, Grace S. Pereira, Juliana B. Guimarães, Elsa Heyman, Romain Meeusen, Thiago T. Mendes, Danusa D. Soares   +12 more
doaj   +1 more source

The acute effects of two different self-myofascial release products on the calf muscle pump and plantar flexion ankle range of motion [PDF]

, 2015
textBackground: Massage can promote healing and recovery following exercise. (Carefelli et al. 1992). Barnes (1990) proposed that myofascial release helps to break up fibrotic fascial adhesions that may restrict joint range of motion (ROM).
Fleisher, Timothy Michael
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Penatalaksanaan Terapi Latihan Pada Kasus Post Open Reduction Internal Fixation Fraktur Cruris 1/3 Distal Dengan Pemasangan Plate And Screw Di Rso Prof. Dr. Soeharso Surakarta [PDF]

, 2015
Background: A fracture is a break of continuity of bone fragments of bone tissue structure may be shifted or complete fracture. Cruris are two long bones tibia and fibula.Namely the location of the distal third of bone fracture in the bone below 1/3 ...
, Maskun Pudjianto, S.MPh, M.Kes, Rizkya, Rinta   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Penatalaksanaan Fisioterapi Pada Kasus Pneumothoraks Dextra Di RSU PKU Muhammadiyah Yogyakarta [PDF]

, 2015
Background: Pneumothorax dextra is a respiratory disorder with symptoms of asphyxia, reduced thorax expansion and functional activity disturbances. The disorder can be overcome by using exercise therapy such as Breathing Exercise, Thoracic Exercise ...
, Isnaini Herawati S.Fis.,S.Pd,.M.Sc, Pratama, Vindo Dwika   +1 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Penatalaksanaan fisioterapi pada kondisi paska operasi medial collateral ligament knee dextra di rs al dr. ramelan surabaya [PDF]

, 2014
Background: The ligaments of the knee joint is also a part of the body that continues constantly under pressure while performing everyday activities. Trauma caused by accidents, falls, or a direct blow to the knee can cause injury to the ligaments at ...
Iswamarokta, Addin Hamzahnor, Sugiono, SS t .FT,   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source