Results 241 to 250 of about 415,808 (314)

Electromyographic examination of a new exercise therapy for the intrinsic and extrinsic foot muscles. [PDF]

J Phys Ther Sci
Kuroyanagi E, Watanabe T, Furusawa H, Tsutsumi M, Kudo S.   +4 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Status Quo analysis of an exercise therapy care model in pediatric oncology during acute therapy: perspectives from patients, parents, siblings, and staff. [PDF]

Front Pediatr
Böhlke L, Simon T, Hero B, Reinke D, Friedrich A, Zoth N, Baumann FT.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Resistance Exercise Therapy After COVID-19 Infection: A Randomized Clinical Trial.

JAMA Netw Open
Berry C, McKinley G, Bayes HK, Anderson D, Lang CC, Gill A, Morrow A, Sykes R, Taggart D, Kamdar A, Welsh P, Dawkes S, McConnachie A, Gray SR.   +13 more
europepmc   +1 more source

Retrospective Cohort Study Analysing Response to Supervised Exercise Therapy and Subsequent Revascularization in Patients with Intermittent Claudication. [PDF]

J Clin Med
Bouch EJ, Austerberry S, Bowling FL, Rogers SK.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Interventional Effects of Small Needle-Knife Combined with Exercise Therapy in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis. [PDF]

J Pain Res
Xu Y, Yang Q, Xu J, Xiao N, Yang X, Yan H, Zhang J, Lu H, Liu X, Sheng L, Zhu R, Huang J, Xie J, Xie Z, Li Z.   +14 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Individualized online exercise therapy aids recovery in pediatric long-COVID-findings from an exploratory randomized controlled trial. [PDF]

Eur J Pediatr
Goretzki SC, Bergelt M, Weis L, Hojeii R, Gauß G, Götte M, Beller R, Benson S, Schönecker A, Marina AD, Gangfuß A, Stehling F, Pentek C, von Loewenich A, Hühne T, Held C, Voigt S, Felderhoff-Müser U, Schündeln MM, Bruns N, Eckert K, Dohna-Schwake C, Brasseler M.   +22 more
europepmc   +1 more source